نتایج جستجو برای: ovarian insufficiency
تعداد نتایج: 183069 فیلتر نتایج به سال:
Premature ovarian insufficiency (POI) is a typical disorder of amenorrhea lasting for a minimum of 4 months. The typical characteristics comprised of declined estrogen and raised serum concentrations of follicle-stimulating hormone (FSH) in women <40-year-old, primarily originating from iatrogenic factors, karyotypic abnormalities, and genetic factors. However, the etiology of POI remains unkno...
Primary ovarian insufficiency (POI) is a genetically heterogeneous disorder that occurs in familial or sporadic fashion. Through whole exome sequencing in a Chinese pedigree with POI, we identified a novel homozygous missense mutation (ENST00000375755: c.1459G > T, p.D487Y) in the MSH5 gene in two sisters with POI. The homologous mutation in mice resulted in atrophic ovaries without oocytes, an...
Abstract Background Premature ovarian insufficiency (POI) is characterized by impairment of function on a continuum before the age 40 years. POI affected multiple factors. Considering new insights from recent gut microbiome studies, this study aimed to investigate relationship between microbial community structure and POI. Methods Subjects were recruited at Shenzhen Maternity & Child Health...
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