Ovarian cancer is the leading cause of death from gynecologic cancer in women worldwide (Kumar et al., 2011), with an estimation of 225,500 women diagnosed with ovarian cancer and 140,200 deaths in 2008 (Lowe et al., 2013). Several risk factors of ovarian cancer have already been identified, such as parity (Pasalich et al., 2013), never breastfeeding (Luan et al., 2013), endometriosis (Vargas-H...

Breast and ovarian cancers are among the 10 leading cancer types in females with mortalities of 15% and 6%, respectively. Despite tremendous efforts to conquer malignant diseases, the war on cancer declared by Richard Nixon four decades ago seems to be lost. Approximately 21,800 women in the US will be diagnosed with ovarian cancer in 2011. Therefore, its incidence is relatively low compared to...

Type 2 diabetes causes structural and functional changes in the myocardium, which is called cardiomyopathy. Diabetic cardiomyopathy (DCM) is a distinct primary disorder process, independent of coronary artery disease, which leads to heart failure in diabetic patients. Also, DCM is a multifaceted disorder that is one of the leading causes of death in elderly and postmenopausal women. Menopause i...

BACKGROUND Glycodelin A (GdA), also known as placental protein 14 (PP14), has been detected in endometrial, cervical and ovarian carcinoma cells. It is suspected to be a marker of human ovarian cancer tissues. MATERIALS AND METHODS We investigated serum, tissue and cyst fluid samples of patients with an ovarian carcinoma in contrast to patients with benign and malignant diseases such as uteri...

A 52-year-old woman presented with abdominal distension. The laboratory data were as follows: white blood cell count, 7.100/mm3; hemoglobin, 12.2g/dL; platelet count, 206.000/mm3; blood urea nitrogen, 16.8mg/dL; serum creatinine, 1.6mg/dL; sodium, 146mEq/L; potassium, 3.2mEq/L; chloride, 94mEq/L; glucose, 110mg/dL; total protein, 8.6g/dL; and albumin, 4.9g/dL. Random urine protein concentration...

BACKGROUND Apoptosis is a highly conserved form of cell death and aberrant regulation of apoptotic cell death mechanisms leads to variety of major human diseases, especially tumor formation. Genetic variations in apoptosis genes may increase susceptibility to ovarian cancer. RESULTS In individual SNP analysis, 12 SNPs in 5 apoptosis pathway genes were significantly associated with ovarian can...

The mutation of K-ras protooncogene was examined in 44 cases of borderline ovarian epithelial tumors and 18 cases of invasive ovarian carcinomas. In borderline tumors, K-ras mutations are a common feature, having been found in 21 of 44 cases (48%). Twenty of the 21 mutations were identified at codon 12, and one was identified at codon 13. A detailed analysis of the mutation pattern of K-ras rev...

In females, menopause, the cessation of menstrual cycling, is associated with an increase in risk for several diseases such as cardiovascular disease, osteoporosis, diabetes, the metabolic syndrome, and ovarian cancer. The majority of women enter menopause via a gradual reduction of ovarian function over several years (perimenopause) and retain residual ovarian tissue. The VCD mouse model of me...

BACKGROUND OVARIAN CARCINOMAS CONSIST OF AT LEAST FIVE DISTINCT DISEASES: high-grade serous, low-grade serous, clear cell, endometrioid, and mucinous. Biomarker and molecular characterization may represent a more biologically relevant basis for grouping and treating this family of tumors, rather than site of origin. Molecular characteristics have become the new standard for clinical pathology, ...

AIM OF THE STUDY Establishing a characteristic pattern for the stromal ovarian tumors. MATERIAL AND METHODS We realized the clinical-statistics analyze of 27 stromal tumors (lot B) from a total of 498 patients with ovarian tumors (lot A), diagnosed and treated between 1999 - 2008 in Elena Doamna Hospital of Obstetrics and Gynecology, lasi. We used the clinical files of these patients, operato...