نتایج جستجو برای: ovar drb1 gene
تعداد نتایج: 1143501 فیلتر نتایج به سال:
We conducted an association study across the human leukocyte antigen (HLA) complex to identify loci associated with multiple sclerosis (MS). Comparing 1927 SNPs in 1618 MS cases and 3413 controls of European ancestry, we identified seven SNPs that were independently associated with MS conditional on the others (each P ≤ 4 x 10(-6)). All associations were significant in an independent replicatio...
BACKGROUND AND AIM Primary biliary cirrhosis (PBC) is a chronic cholestatic disease of autoimmune origin and has a genetic component. Although it has been reported that the prevalence of the HLA-DRB1*08 allele is high in various populations, the prevalence of HLA alleles in Mexican PBC patients has not been described. The aim of this study was to quantify the prevalence of HLA-B/-DR alleles in ...
BACKGROUND The individual contribution of genes in the HLA region to the risk of developing type 1 diabetes (T1D) is confounded by the high linkage disequilibrium (LD) in this region. Using a novel approach we have combined genetic association data with information on functional protein-protein interactions to elucidate risk independent of LD and to place the genetic association into a function...
Pathogen-driven balancing selection determines the richness of human leukocyte antigen (HLA) alleles. Changes in the pathogen spectrum may cause corresponding changes in HLA loci. Approximately 700 years ago, a Mongolian population moved from the north of China to the Yunnan region in the south of China. The pathogen spectrum in the south of China differs from that in the north. In this study, ...
objective: type 1 diabetes mellitus (t1d) is an autoimmune and multifactorial disorder. subsequent analysis on human leukocyte antigen ( hla) region shows that hla-drb1 and -dqb1 genes have the strongest association with t1d. in this study, for the first time, we investigated the influence of gender on the hla-drb1 and -dqb1 association with type 1 diabetes mellitus in iranian patients in order...
The present study was aimed to analyze the frequencies of human leukocyte antigen (HLA)-A, -B, and -DRB1 alleles and A-B-DRB1, A-B, A-DRB1 and B-DRB1 haplotypes in inhabitants of Guizhou province, China. All samples were typed in the HLA-A,-B, and -DRB1 loci using the polymerase chain reaction-reverse sequence specific oligonucleotide probe (PCR-rSSOP) method and HLA polymorphisms were analyzed...
مقدمه :یکی از انواع شایع آلرژی رینیت آلرژی است .عامل اصلی این نوع آلرژی گرده گل ها، درختان و علف های هرز است .این گیاهان به طور عمده در بهار و تابستان گرده افشانی می کنند . یکی از این گیاهان آرتمیسیا ولگاریس است که در اواخر تابستان گرده افشانی می کند و از شیوع با?یی در سراسر جهان از جمله ایران برخوردار است . ارتباط مهمی بین آلل های hla-drb1 و آلرژی به گیاه آرتمیسیا ولگاریس در شهرستان سبزوار واق...
The presence of oligoclonal bands (OCB) in cerebrospinal fluid (CSF) is a typical finding in multiple sclerosis (MS). We applied data from Norwegian, Swedish and Danish (i.e. Scandinavian) MS patients from a genome-wide association study (GWAS) to search for genetic differences in MS relating to OCB status. GWAS data was compared in 1367 OCB positive and 161 OCB negative Scandinavian MS patient...
Susceptibility to multiple sclerosis (MS) has been linked mainly to the HLA-DRB1 locus, with the HLA-DR15 haplotype (DRB1*1501-DQA1*0102-DQB1*0602-DRB5*0101) dominating MS risk in Caucasians. Although genes in the HLA-II region, particularly DRB1*1501, DQA1*0102-DQB1*0602, are in tight linkage disequilibrium, genome-wide-association, and gene candidate studies identified the DRB1*15:01 allele a...
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