Ovine herpesvirus 2 (OvHV-2), is the causative agent of sheep-associated malignant catarrhal fever (SA-MCF), a generally fatal disease of cattle and other captive wild ruminants. Information on the OvHV-2 strains circulating in South Africa (SA) and other African countries with regard to genetic structure and diversity, and pattern of distribution is not available. This study aimed to character...

OBJECTIVE Although our previous studies have confirmed that 1, 3, 8-trihydroxy-6-methylant hraquinone (emodin) inhibits migration and invasion in epithelial ovarian cancer (EOC) cells, the underlying molecular mechanism remains unknown. Here, the aim was to investigate the effects of emodin on EOC cells and to study further the mechanism underlying this process, both in vitro and in vivo. MAT...

We obtain several averaging lemmas for transport operator with a force term. These lemmas improve the regularity yet known by not considering the force term as part of an arbitrary right-hand side. We compare the obtained regularities according to the space and velocity variables. Our results are mainly in L 2 , and for constant force, in L p for 1 < p ≤ 2. Keywords: averaging lemma – force ter...

Although ursolic acid isolated from Oldenlandia diffusa (Rubiaceae) was known to have anticancer activities in prostate, breast and liver cancers, the underlying mechanism of ursolic acid in ovarian cancer cells was not investigated so far. In the present study, the apoptotic mechanism of ursolic acid was elucidated in SK-OV-3 ovarian cancer cells by 2,3-bis(2-methoxy-4-nitro-5-sulphophenyl)-2H...

Orf virus (ORFV), a species of the genus Parapoxvirus of the family Poxviridae, causes non-systemic, highly contagious, and eruptive disease in sheep, goat, and other wild and domestic ruminants. Our previous work shows orf to be ubiquitous in the Fujian Province of China, a region where there is considerable heterogeneity among ORFVs. In this study, we sequenced full genomes of four Fujian goa...

Oncolytic viruses (OVs) target and destroy cancer cells while sparing their normal counterparts. These viruses have been evaluated in numerous studies at both pre-clinical and clinical levels and the recent Food and Drug Administration (FDA) approval of an oncolytic herpesvirus-based treatment raises optimism that OVs will become a therapeutic option for cancer patients. However, to improve cli...

Granulins are a family of protein growth factors that are involved in cell proliferation. An orthologue of granulin from the human parasitic liver fluke Opisthorchis viverrini, known as Ov-GRN-1, induces angiogenesis and accelerates wound repair. Recombinant Ov-GRN-1 production is complex and poses an obstacle for clinical development. To identify the bioactive region(s) of Ov-GRN-1, four trunc...

The systemic administration of oncolytic virus (OV) is often inefficient due to clearance of the virus by host defense mechanism and spurious targeting of non-cancer tissues through the bloodstream. Cell mediated OV delivery could hide the virus from host defenses and direct them toward tumors: Mesenchymal and neural stem cells have been described to possess tumor-homing ability as well as the ...

The aim of this paper is to solve the fixed point problems : v = Ov, with Ov(x) def = max(Lv(x), Bv(x)), x ∈ E , (1) where E is a finite set, L is contractive and B is a nonexpansive operator and v = Ov, with Ov(x) def = max(sup w Lv(x), sup z Bv(x)), x ∈ E , (2) where W and Z are general control sets, the operators L are contractive and operators B are nonexpansive. For these two problems, we ...

This paper aims to give a short but self-contained introduction into the theory of (wheeled) props, properads, dioperads and operads, and illustrate some of its key ideas in terms of a prop(erad)ic interpretation of simplicial and permutahedra cell complexes with subsequent applications to the HochschildKostant-Rosenberg type isomorphisms. Let V be a graded vector space over a field K and OV :=...