OBJECTIVE Genetic factors play an important role in osteoarthritis (OA) etiology and ADAM12 gene polymorphisms may be involved. This study tried to examine the single-nucleotide polymorphisms (SNPs) of ADAM12 for their association with knee OA susceptibility in a Chinese Han population. METHODS The rs3740199, rs1871054, rs1278279, and rs1044122 SNPs in ADAM12 gene were genotyped in 152 subjec...

BACKGROUND The purpose of this study was to examine the relationship between self-reported falls, doctor-diagnosed knee osteoarthritis (OA), and health-related quality of life (HRQoL). We hypothesized that falls and knee OA would be associated with poor HRQoL on both disease-specific and generic measures. METHODS This cross-sectional study used data from the publicly available Osteoarthritis ...

We evaluated the relationship between altered foot function and knee osteoarthritis through a specific comparison of toe grip strength in older women with and without knee osteoarthritis. Participants were 120 women with knee osteoarthritis (OA group) and 108 healthy community-dwelling women with no history of knee pain and lower limb surgery (control group). The following factors and outcome v...

Osteoarthritis (OA) is a degenerative joint disorder and one of the leading causes of disability in elderly. Tai Chi is seen to be effective in relieving symptoms of OA knee joint. The main aim of this study is to design a Tai Chi program and a strength training program for the elderly with knee OA and to compare the effects of these programs on the range of motion, gait, pain and balance. 20 p...

We report a study of 112 patients with primary anteromedial osteoarthritis of the knee and their families. Sibling risk was determined using randomly selected single siblings. Spouses were used as controls. The presence of symptomatic osteoarthritis was determined using an Oxford knee score of > or= 29 supported by a Kellgren and Lawrence radiological score of II or greater. Using Fisher's exac...

BACKGROUND Osteoarthritis (OA) is a degenerative joint disease involving the cartilage and many of its surrounding tissues. Disease progression is usually slow but can ultimately lead to joint failure with pain and disability. OA of the hips and knees tends to cause the greatest burden to the population as pain and stiffness in these large weight-bearing joints often leads to significant disabi...

BACKGROUND The intent of this study was to examine and compare the ability to detect change of two patient reported outcome (PRO) instruments that use a computerized adaptive test (CAT) approach to measurement. The Patient Reported Outcomes Measurement Information System (PROMIS®) Physical Function scale is a generic PRO, while the Osteoarthritis Computerized Adaptive Test (OA-CAT) is an osteoa...

Objective: The study aim to establish the effect of single-session Kinesio Taping (KT) application upon function, pain, and dynamic balance in older women with knee osteoarthritis (OA).
 Materials Methods: Thirty-women unilateral (OA) were included. A KT intervention was applied quadriceps-femoris hamstrings muscles. All assessments performed three times, before taping, 30 minutes 48 hours...

OBJECTIVE This study reports the development of the OsteoArthritis Questionnaire (OA-Quest) - a new measure designed to comprehensively capture the potentially modifiable burden of osteoarthritis. DESIGN Item development was guided by the a priori conceptual framework of the Personal Burden of Osteoarthritis (PBO) which captures 8 dimensions of osteoarthritis burden (Physical distress, Fatigu...