Ipsilateral displaced acetabular and femoral shaft fractures represent a dilemma for orthopedic surgeons because antegrade femoral nailing may complicate a Kocher-Langenbeck acetabular exposure. The goals of this study were to review the results of ipsilateral femoral and acetabular fractures treated with antegrade femoral nailing and a Kocher-Langenbeck approach and to evaluate the assertion t...

Longitudinal bone growth is determined by endochondral ossification at the growth plate, which is located at both ends of long bones and vertebrae, and involves many systemic hormones and local regulators. C-type natriuretic peptide (CNP), a third member of the natriuretic peptide family, occurs at the growth plate and acts locally as a positive regulator of endochondral ossification through th...

OBJECTIVES Recent biomedical research suggests that, in modern human populations, individuals may vary in their inherent tendency toward bone formation at skeletal and extra-skeletal locations. However, the nature of this phenomenon is incompletely understood, and the extent to which it might apply to past populations is unclear. It is hypothesized that if there is inter-individual variation in...

INTRODUCTION Ossification of the ligamentum flavum (OLF) of the spine is associated with serious neurologic compromise, but the pathomechanism of this process remains unclear. The objective of this study was to investigate the pathomechanism of the ossification process, including the roles of various transcriptional factors in the ossification of human thoracic ligamentum flavum. METHODS Sect...

Acetabular labral ossification is an uncommon condition. We present a case of bilateral idiopathic acetabular labral ossification with no predisposing factor. The differential diagnosis of its plain radiographic appearance is discussed.

FGFR3 gain-of-function mutations lead to both chondrodysplasias and craniosynostoses. Achondroplasia (ACH), the most frequent dwarfism, is due to an FGFR3-activating mutation which results in impaired endochondral ossification. The effects of the mutation on membranous ossification are unknown. Fgfr3(Y367C/+) mice mimicking ACH and craniofacial analysis of patients with ACH and FGFR3-related cr...

RATIONALE Hypoplasia with an intact posterior arch of the atlas and ossification of the posterior atlantoaxial membrane (PAAM) are individually rare. PATIENT CONCERNS The patient presented with a 6-month history of progressive weakness and paresthesia of his lower extremities. DIAGNOSES Cervical myelopathy resulting from atlas hypoplasia and ossification of the posterior atlantoaxial membra...

Eighty rats out of 233 developed malignant tumors in the stomach and small intestine by administration of 100 micrograms/ml N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) in drinking water for 28 weeks. Fifteen lesions (30%) among the 50 small intestinal carcinomas showed ossification in the tumor, while none in the sarcomas (12 lesions) or gastric adenocarcinomas (59 lesions) showed ossification....

Large-area craniofacial defects remain a challenge for orthopaedists, hastening the need to develop facile and safe tissue engineering strategy; osteoconductive material combination of optimal growth factors microenvironment should be considered. Faced with unmet need, we propose that abundant cytokines chemokines can secreted from bone defect, provoking infiltration endogenous stem cells assis...

Dysphagia is associated with poor quality of life, and pneumonia due to aspiration life-threatening. Cervical ossification the anterior longitudinal ligament (C-OALL) one causes dysphagia, we report two cases in which dysphagia improved after surgery. Case 1: A 76-year-old man had C-OALL greater than 16 mm developed myelopathy. fall resulted upper lower limb insufficiency paralysis, posterior d...