نتایج جستجو برای: ospa
تعداد نتایج: 363 فیلتر نتایج به سال:
BACKGROUND Lyme borreliosis is caused by Borrelia burgdorferi sensu stricto in the USA and by several Borrelia species in Europe and Asia, but no human vaccine is available. We investigated the safety and immunogenicity of adjuvanted and non-adjuvanted vaccines containing protective epitopes from Borrelia species outer surface protein A (OspA) serotypes in healthy adults. METHODS Between Marc...
Although the existing deep-learning-based hyperspectral image (HSI) denoising methods have achieved tremendous success, recovering high-quality HSIs in complex scenes that contain mixed noise is still challenging. Besides, these not fully explored local and global spatial–spectral information of HSIs. To address above issues, a novel HSI removal network called subspace projection attention resi...
well defined, thus facilitating the delineation of T-cell specificities (J. Sieper, Benjamin-Franklin Free University, Berlin, Germany) that might contribute to the conversion of immunity into joint pathology. B.T. Huber (Tufts University School of Medicine, Boston, MA, USA) demonstrated that the Borrelia burgdorferi outer surface protein A (OspA) plays a major role in the induction of crossrea...
Borrelia burgdorferi infection causes Lyme borreliosis in humans, a condition which can involve a systemic spread of the organism to colonize various tissues and organs. If the infection is left untreated by antimicrobials, it can lead to manifestations including, arthritis, carditis, and/or neurological problems. Identification and characterization of B. burgdorferi outer membrane proteins tha...
BACKGROUND Although European Borrelia burgdorferi sensu lato isolates have been divided into five genospecies, specific tools for the serotype characterization of only three genospecies are available. Monoclonals antibodies (mAbs) H3TS, D6 and I17.3 identify B. burgdorferi sensu stricto (ss.), B. garinii and B. afzelii respectively, but no mAbs are available to identify B. valaisiana. In the sa...
Vaccination with outer surface protein A (OspA) of Borrelia burgdorferi prevents subsequent infection and disease in both laboratory animals and humans with high efficacy. OspA-based immunity, however, does not affect established infection due to the loss of OspA expression in the vertebrate host. We show here that repeated passive transfer of mouse and/or rabbit immune sera to recombinant GST-...
A commercially available recombinant OspA vaccine (Recombitek rLyme, Merial Ltd.) was used to immunize dogs against natural infection by Borrelia burgdorferi in Connecticut, an area highly endemic for Lyme disease. A C6 ELISA kit was used to determine infection rates in both vaccinated dogs as well as an unvaccinated control group. Study dogs were patients at a small animal practice in Old Lyme...
The aim was to find if there is variability in the production of specific antibodies by BALB/c mice to certain antigens of three individual Borrelia afzelii (dead cell suspension) strains originally isolated from different sources. Analysis of the borrelian proteins immunogenicity was performed and determined to particular strains by immunoblotting. Some differences in production of specific Ig...
The major outer surface proteins of Lyme disease spirochaetes are differentially expressed in different isolates. Borrelia afzelii strain F1 expresses none, or very low amounts, of the OspA and OspB proteins. To elucidate the mechanisms that control the expression of these abundant surface proteins the ospAB operon of B. afzelii F1 was cloned, sequenced and compared to the previously sequenced ...
Although recombinant outer surface protein A (OspA) of Borrelia burgdorferi protects mice against injected Lyme disease spirochetes, the mode of protection has not yet been explored. Indeed, the efficacy of vaccine-induced immunity against a realistic vector-mediated challenge remains unexplored. Accordingly, we determined whether this immunogen protects mice against spirochetes delivered by ny...
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