Oral Submucous Fibrosis (OSMF) is a chronic, insidious, disabling disease of oral mucosa, oropharynx, and rarely, the larynx affecting millions people worldwide with prevalence rate 0.4% in Indian rural population. It results difficulty mouth opening can be to patient. needs timely diagnosis thus appropriate treatment administered depending on degree involvement. A case occurring 55 year old ma...

One precancerous condition with a high potential to turn into malignancy and pose risk is OSMF (oral submucous fibrosis) which mainly affects the young subjects globally as well in India. The etiology of attributed gutkha chewing habit. Another predominant etiologic factor governing etiopathogenesis malignant premalignant lesions Candida species. Our aim present clinical study was conducted ass...

INTRODUCTION Concurrent with the progression of a non- diseased epithelium to the pre-cancerous epithelium to carcinoma, the stroma also undergoes modifications. Myofibroblasts are important stromal cells that play a crucial role in carcinogenesis. The current study investigated the presence of myofibroblasts in healthy oral mucosa, potentially malignant disorders (PMDs) and squamous cell carci...

AIM AND OBJECTIVE To evaluate the therapeutic efficacy of oral pentoxifylline in the treatment of oral submucous fibrosis (OSMF) patients by assessing the clinical symptoms such as burning sensation, mouth opening, and submucosal layer thickness and echogenicity using ultrasonography, both pre- and post-operatively. MATERIALS AND METHODS Thirty study subjects were included in the study and di...

Objective: This study was designed to determine the effect of Pentoxifylline on the clinical and pathologic course of Oral Submucous Fibrosis (OSMF). Methods: This study was conducted as a randomized clinical trial incorporating a control group (antioxidant therapy, Tab Lycored once daily) in comparison to Pentoxifylline test cases (400mg 3 times daily, tablets). The treatment period was 3 mont...

Oral submucous fibrosis (OSMF), which presents with a severe degree of trismus, is a great surgical challenge. The surgical procedures include excision of fibrous bands with or without coverage of the surgically created defect. The use of vascularised flaps such as the palatal pedicled flap, tongue flaps, use of buccal fat pad and nasolabial flaps are becoming increasingly popular. We present a...

Rationale (Hypothesis): The antioxidant,anti-inflammatory,immunomodulatory and anti-tumorigenic properties of natural plant’s extracts like aloe Vera curcumin may produce beneficial therapeutic effects on OSMF patients lead to their symptomatic relief. Also, increase in the tissue elasticity with help oral physiotherapy excercises , would reinforcing increment mouth opening. Aim: aim study is c...

Areca quid chewing related oral mucosal lesions are potential hazard to a large population worldwide. Commercially freeze dried products such as pan masala, guthka and mawa have high concentration of areca nut per chew and appear to cause OSMF more rapidly than by self prepared conventional betel quid that contain smaller amounts of areca nut. The basic constituent of areca nut is either raw or...