Interleukin 6 (IL-6), oncostatin M (OSM) and leukaemia-inhibitory factor (LIF) share a common signal-transducing subunit in each of their receptors and thus mediate an overlapping spectrum of biological activities. Although all of these cytokines stimulate the production of alpha1-proteinase inhibitor (alpha1-PI) in hepatocyte-derived cells, only OSM is able to up-regulate levels of this inhibi...

Delivering raw geospatial data to mobile devices is an interesting and challenging computational and user-interface problem. Geospatial data can be rendered in real-time on the mobile device using appropriate visualisation software running on the mobile device operating system. Currently the majority of approaches in delivering geospatial data to mobile devices provide pre-rendered maps (tiles,...

BACKGROUND Rheumatoid arthritis (RA) is an autoimmune disease associated with chronic inflammatory arthritis. TNF-α and OSM are pro-inflammatory cytokines that play a key role in RA progression. Thus, reducing the effects of both cytokines is practical in order to relieve the progression of the disease. This current study is interested in sesamin, an active compound in sesame seeds. Sesamin has...

The cytokine oncostatin M (OSM) is a member of the interleukin (IL)-6 family, known to down-regulate expression of drug metabolizing cytochromes P-450 in human hepatocytes. The present study was designed to determine whether OSM may also impair expression of sinusoidal and canalicular drug transporters, which constitute important determinants of drug hepatic clearance. Exposure of primary human...

Injury to retinal ganglion cell (RGC) axons leads to selective loss of RGCs and vision. Previous studies have shown that exogenous neurotrophic factors promote RGC survival. We investigated the neuroprotective effects of oncostatin M (OSM), a member of the IL-6 family of cytokines, on pattern electroretinogram (PERG) and RGC survival after optic nerve crush (ON-crush) in the mouse. BALB/C mice ...

Accumulating evidence suggests that adventitial fibroblasts play a significant role in contributing to inflammation of the arterial wall and pathogenesis of atherosclerosis. The effects of gp130 cytokines on these cells (including oncostatin M-[OSM] and IL-6), some of which have been implicated in atherosclerosis, are currently unknown. Experiments were performed to determine whether gp130 cyto...

Land Use/Land Cover Maps (LULCM), fundamental for many areas of application, are usually generated through the classification of satellite imagery. However, their creation is time consuming and therefore updated LULCM are seldom available. The OpenStreetMap (OSM) collaborative project collects a rich set of vector data provided by volunteers at a global scale. It has already been shown that OSM...

Monocytes and macrophages (m) are plastic cells whose functions are governed by microenvironmental cues. Wound fluid bathing the wound tissue reflects the wound microenvironment. Current literature on wound inflammation is primarily based on the study of blood monocyte-derived macrophages, cells that have never been exposed to the wound microenvironment. We sought to compare pair-matched monocy...

OSM is a novel approach to usability analysis and design that focuses on the quality of fit between the concepts the user is working with and those represented within supporting systems. It focuses not on tasks and procedures but on ontology-that is, the conceptual objects (entities and their attributes) that are embodied in a system, and the mismatches between those concepts and the ones broug...