The effects of folinic acid on amethopterin-induced inhibition of growth, purine nucleotide biosynthesis, and DNA thymine formation were measured in Ehrlich ascites cells in vivo. Folinic acid prevented the amethopterin-induced prolongation of survival time of tumor-bearing mice at folinic acid levels which caused complete reversal of the inhibition of glycine-2-C14 incorporation into purines b...

Sheep’s milk is an important source of bioactive substances that have health-promoting functions for the body. The valuable composition sheep’s due to high content fatty acids, immunoglobulins, proteins, hormones, vitamins and minerals. Many biopeptides found in antibacterial, antiviral anti-inflammatory properties. also show anticancer milk, thanks its CLA orotic acid, prevents occurrence type...

A facile hydrogelation of a p-pyridylenevinylene derivative (PV) bearing oxyethylene chains in the presence of orotic acid (OA) occurs via various non-covalent interactions. Depending on the PV : OA molar ratio, the hydrogel shows vesicle to either cluster-type aggregate or fiber transformation. Visual color tuning, stimuli-responsiveness and injectable properties of the hydrogel are also obser...

Bovine serum is an essential factor for the continuous in vitro growth of Babesia bovis parasites. Culture media typically contain 40% (v/v) of bovine serum. In the present study assays with low-serum media were performed. The growth of B. bovis Mo7 was successively lower in media with 30%, 20% and, principally, with 10% of serum. Without serum, the parasites were not able to propagate. In medi...

The title complex, [Co(C(5)H(2)N(2)O(4))(C(14)H(8)N(4))(2)]·2H(2)O, features a slightly distorted octa-hedral geometry for Co due to the sterical requirements of the orotic acid and pyrazino[2,3-f][1,10]phenanthroline ligands. Inter-molecular hydrogen bonding between the uncoordinated water mol-ecules and the ligand stablizes the structure of the complex.

Treatment with three daily doses (3-10 gg/gm each) of thioTEPA inhibited incorporation of radioactive glycine and lysine into protein, of glycine into acid-soluble nucleotides, and of glycine, formate, adenine, and orotic acid into nucleic acids of L-1 mouse tumor in a majority of experiments. In tumors from mice having other treatment schedules and in livers from all groups no definite change ...