IntroductionLife expectancy is rising and consequently also the number of older patients with head neck cancer. Different treatment regimens are often applied for patients. The aim this study to investigate how patterns survival rates have changed over past 20 years in squamous cell carcinoma (HNSCC).MaterialsPatient tumour characteristics, 5-year data from Netherlands Cancer Registry aged ≥60 ...

OBJECTIVES To compare chi-squared automatic interaction detection (CHAID) classification trees vs the seventh edition of the TNM classification for patients with head and neck squamous cell carcinoma and to assess whether CHAID classification trees might improve results obtained with the TNM classification. DESIGN Patient disease was classified according to CHAID classification trees and the ...

This study evaluates the anatomic fidelity of several commercially available pediatric and adult manikins, including airway task trainers, which could be used in aerodigestive procedure training. Twenty-three experienced otolaryngologists assessed the aerodigestive anatomy of 5 adult and 5 pediatric manikins in a passive state, using rigid and flexible endoscopy. Anatomic fidelity was rated on ...

Transoral approach to the cervico-medullary junction is a well-established procedure. However oropharyngeal complications in the form of soft tissue morbidity postoperatively do occur. We report a case of a teenage boy with traumatic quadriparesis secondary to compression of the cervico-medullary junction by an os odontoideum. Decompression was done via transoral approach through a tubular retr...

background: delayed reporting resulting in advanced stage disease is a common problem in indian cancer patients. this study analysed the impact of various sociodemographic and psychosocial factors on the delayed reporting to healthcare professional (hcp) in oral and oropharyngeal cancer patients. methods: this cross sectional observational study was conducted using a structured questionnaire. q...

The purpose of this study was to suggest general guidelines in the management of the N0 neck of oral cavity and oropharyngeal adenoid cystic carcinoma (AdCC) in order to improve the survival of these patients and/or reduce the risk of neck recurrences. The incidence of cervical node metastasis at diagnosis of head and neck AdCC is variable, and ranges between 3% and 16%. Metastasis to the cervi...

In this issue of Clinical Infectious Diseases, Vazquez et al. [1] demonstrate in a well-conceived and well-conducted multicenter trial that posaconazole is equivalent in efficacy to fluconazole in the treatment of oropharyngeal candidiasis in HIV-infected patients. Patients given posaconazole also experienced fewer clinical relapses of oro-pharyngeal candidiasis than did patients given fluconaz...

OBJECTIVES/HYPOTHESIS Dysphagia is still a treatment-related morbidity, despite advances in treatment modalities for oral and oropharyngeal squamous cell carcinoma. This systematic review aimed to analyze the effects of swallowing outcomes of patients with oral or oropharyngeal squamous cell carcinoma treated with primary surgery with primary free flap reconstruction, with or without adjuvant t...

BACKGROUND Therapeutic decisions in recurrent oral and oropharyngeal squamous carcinoma (SCC) remain controversial. METHODS Two hundred forty-six consecutive patients who underwent salvage surgery for recurrent squamous cell carcinoma (SCC) of the oral cavity and oropharynx were studied. The tumor sites were lip, 33 cases; oral cavity, 143; oropharynx, 70. The previous treatment was surgery i...

Glutathione S-transferase (GST) enzyme activity, GST isoenzyme composition and glutathione (GSH) concentration were assessed in normal and squamous cell carcinoma specimens of 14 patients with oral or oropharyngeal cancer and 11 patients with laryngeal cancer. Comparing malignant with normal oral/oropharyngeal tissues, no significant differences in GSH content, GST enzyme activity or isoenzyme ...