congenital heart disease. Am J Cardiol 2012;109:1657–63. [3] Geyer S, Norozi K, Buchhorn R, Wessel A. Chances of employment in women and men after surgery of congenital heart disease: comparisons between patients and the general population. Congenit Heart Dis 2009;4:25–33. [4] Kamphuis M, Vogels T, Ottenkamp J, Van Der Wall EE, Verloove-Vanhorick SP, Vliegen HW. Employment in adults with congen...

BACKGROUND The number of people with disabilities in Brazil and worldwide has grown substantially in recent decades. Cross-cultural quality of life instruments can be helpful in the development of interventions designed to meet the needs of this population and contribute to rational allocation of resources. This study sought to provide evidence of validity and reliability the Brazilian Portugue...

hypertension crisis is one of the main health problems and its effective treatment is of high importance. for this purpose, fast-disintegrating and sustained release formulations of captopril, as a drug of choice, were prepared using conventional mucoadhesive polymers hydroxypropyl methylcellulose (hpmc), sodium carboxymethyl cellulose (na-cmc), hydroxypropyl cellulose (hpc), carbopol 934 (cp93...

Orally disintegrating olanzapine (ODO) is a rapid-dissolving formulation of olanzapine which disintegrates in saliva almost immediately, developed as a convenient and adherence-enhancing alternative to the standard olanzapine-coated tablet (SOT). Clinical studies, which form the basis of this review, have shown ODO and SOT to have similar efficacy and tolerability profiles. However, ODO appears...

The present study investigates the use of glyceryl palmitostearate (Precirol ATO 5 – coded PATO) as binder in orally disintegrating tablets (ODT), prepared by melt granulation. PATO has been mentioned in literature for its lipophilic nature and fine powder properties, providing excelent coating and slow release of active drugs, but it can also be used for taste masking purposes, with possible a...

Recent developments in fast disintegrating tablets have brought convenience in dosing to pediatric and elderly patients who have trouble in swallowing tablets. The objective of the present study was to prepare the fast disintegrating tablet of Cetirizine Hydrochloride for allergic and respiratory disorders. As precision of dosing and patient's compliance become important prerequisite for a long...

Mannitol is an essential excipient employed in orally disintegrating tablets due to its high palatability. However its fundamental disadvantage is its fragmentation during direct compression, producing mechanically weak tablets. The primary aim of this study was to assess the fracture behaviour of crystalline mannitol in relation to the energy input during direct compression, utilising ball mil...

NEW DRUG APPROVALS Adzenys XR-ODT for ADHD The FDA has given the green light to Adzenys XR-ODT (Neos Therapeutics) for the treatment of attention -deficit/ hyperactivity disorder (ADHD) in patients 6 years of age and older. With this approval, the product is the first extended-release orally disintegrating tablet (ODT) for this indication. Adzenys XR-ODT contains amphetamine loaded onto a mixtu...