OBJECTIVE The N-methyl-D-Aspartate (NMDA) receptor has been proposed as a primary target for the treatment of neuropathic pain. The aim of the present study was to perform a meta-analysis evaluating the effects of (individual) NMDA receptor antagonists on neuropathic pain, and the response (sensitivity) of individual neuropathic pain disorders to NMDA receptor antagonist therapy. DESIGN PubMe...

overview of oral sucrose analgesia for infants. The administration of oral sucrose, with or without nonnutritive sucking (NNS), has been the most frequently studied nonpharmacological intervention for relief of procedural pain in neonates. Oral sucrose has a beneficial role in pain prevention and management for infants, including babies in the emergency department. Although most research on ora...

Pain in the oral and craniofacial system represents a major medical and social problem. Indeed, a U.S. Surgeon General’s report on orofacial health concludes that, ‘‘. . .oral health means much more than healthy teeth. It means being free of chronic oral-facial pain conditions. . .’’ [172]. Community-based surveys indicate that many subjects commonly report pain in the orofacial region, with es...

To evaluate the efficacy and tolerability of oxycodone in cancer-related pain, we conducted a systematic review of randomized controlled trials. Four studies, comparing oral oxycodone with either oral morphine (n = 3) or oral hydromorphone (n = 1), were suitable for meta-analysis. Standardized mean differences in pain scores comparing oxycodone with control groups were pooled using random-effec...

Background: One of the symptoms of mucositis caused by chemotherapy is pain. Mucositis management is initiated by assessment of oral hygiene and management of pain. Many uses have been mentioned for Satureja hortensis in traditional medicine. The study was carried out with the aim of determining the effect of Satureja hortensis extract mucoadhesive gel of 1% on severity of mucositis-induced pai...

Introduction. Chronic pain of the oral cavity is a long-term condition and like all other types of chronic pain is associated with numerous comorbidities such as depression or anxiety. Case Presentation. This is a case of a 93-year-old patient suffering from chronic oral cavity pain who repeatedly stabbed his palate due to ongoing local pain, over the last few months, which he could not further...

We conducted a randomized, controlled, double-blind, prospective study to evaluate the effect of intraoperative bupivacaine injection in tonsillar fossa to control the postoperative pain following dissection method tonsillectomy in 40 patients. 20 patients were injected with bupivacaine 10ml of 0.25% and 20 patients were injected with normal saline. Following the surgery we completed the questi...

Statement of the Problem A significant proportion of patients undergoing chemotherapy or radiotherapy suffer from mucositis. The first symptom of oral mucositis is pain. Severe pain, burning sensation, and discomfort in the oral cavity make it difficult to continue treatment and even continue living in these patients. Purpose The aim of this study was to evaluate and compare the effect of ami...

UNLABELLED Previous study has shown that the use of intramuscular (IM) steroid leads to improved symptoms in patients with group A beta-hemolytic streptococcus (GABHS). OBJECTIVE To compare oral with IM steroids as an adjunct to antibiotic therapy in the treatment of acute exudative pharyngitis. The null hypothesis was that there would be no difference in effectiveness of oral versus IM stero...

INTRODUCTION Every newborn infant is screened for hypothyroidism and phenylketonuria by blood sampling, during the first week of life, but there is not a simple and efficient method to reduce pain during the procedure. OBJECTIVES Prospective randomised trial, to assess if the administration of oral glucose, paracetamol or EMLA, given individually, can reduce the pain caused in newborns by hee...