In order to reduce the ulcerogenic effect of ibuprofen, its carboxylic group has been converted into 5-membered heterocyclic rings. Various 1,3,4-oxadiazoles (3-8, 16-21), 1,2,4-triazoles (22-27), 1,3,4-thiadiazoles (28-30), and 1,2,4-triazine (9) derivatives of ibuprofen were prepared by cyclization of 2-(4-i-butylphenyl) propionic acid hydrazide (2) and N1-[2-(4-i-butylphenyl)-propionyl]-N4-a...

OBJECTIVE To compare the performance of ibuprofen vs codeine for postoperative pain management after tonsillectomy as measured by need for emergency department (ED) treatment for pain and/or dehydration. STUDY DESIGN Retrospective case series with chart review. SETTING Tertiary children's hospital. SUBJECTS AND METHODS Consecutive series of patients who underwent tonsillectomy with or wit...

BACKGROUND Soft tissue injuries commonly present to the emergency department (ED), often with acute pain. They cause significant suffering and morbidity if not adequately treated. Paracetamol and ibuprofen are commonly used analgesics, but it remains unknown if either one or the combination of both is superior for pain control. OBJECTIVES To investigate the analgesic effect of paracetamol, ib...

Long-term treatment with ibuprofen twice daily, at doses that achieve peak plasma concentration (Cmax) >50 microg/ml, slows progression of lung disease in patients with cystic fibrosis (CF). Previous data suggest that Cmax >50 microg/ml is associated with a reduction in neutrophil (PMN) migration into the lung and that lower concentrations are associated with an increase in PMN migration. To es...

Polyelectrolyte complexes (PECs) are attractive carriers with recognized potential to enhance oral delivery of poorly soluble high-dosed low-molecular-weight drugs. The formulation solid dosage forms requires the drying PECs, which may affect their physicochemical and biopharmaceutical properties. aim this study was investigate effect spraydrying on properties ibuprofen-loaded chitosan/xanthan ...

Ibuprofen and aspirin are frequently used to relieve inflammation, pain, fever. These the two most significant non-steroidal anti-inflammatory drugs (NSAIDs). They prevent development of prostaglandin by blockampounds have been assessed ibuprofen as well quantum mechanical computations. Density functional theory (DFT) with B3LYP/6-31G+ basis function has elucidate thermo-chemical, molecular orb...

recurrent aphthous stomatitis (ras) is the most common and painful oral inflammatory lesion with an unknown etiology. this study aims to determine the therapeutic effects of ibuprofen, diphenhydramine and aluminum magnesium simethicone (almgs) syrup on reducing oral aphthous ulcer pain.thirty-one patients with ras participated in this double-blind clinical trial. subjects were randomly divided ...

Solvent cast films are used as oral strips with potential to adhere to the mucosal surface, hydrate and deliver drugs across the buccal membrane. The objective of this study was the formulation development of bioadhesive films with optimum drug loading for buccal delivery. Films prepared from κ-carrageenan, poloxamer and polyethylene glycol or glycerol, were loaded with ibuprofen as a model wat...

Introduction: To systematically review high-quality randomized controlled trials (RCTs) and meta-analysis on the effectiveness of use of ibuprofen and low-level laser therapy (LLLT) for pain control during fixed orthodontic appliance therapy. Materials and methods: A web-based systematic search of PubMed and Medline database using relevant keywords was performed in August 2016 limited to the En...

Six β-hydroxy-β-aryl propanoic acids were synthesised using a modification of Reformatsky reaction which has already been reported. These acids belong to the aryl propanoic acid class of compounds, structurally similar to the NSAIDs, such as ibuprofen, and an anti-inflammatory activity is thus expected. The aim of this work was to determine anti-inflammatory activity, examine gastric tolerabili...