It is well known scientifically that ACE (Angiotensin converting enzyme) inhibitors prevent the development and progression of incipient or established nephropathy and delay the progression of diabetic retinopathy hence these drugs are routinely prescribed with the oral anti-diabetic drugs in these conditions. The actual scenario of impact of ACE inhibitors on blood glucose is still controversi...

The hypoglycemic effect of ethanolic extract of Casearia esculenta was investigated on alloxan induced diabetic rats. The blood glucose levels were measured at 0, 1, 2 and 3 h after the treatment. The ethanolic extract of C. esculenta (250 mg/kg) reduced the blood glucose of normal rat from 85.50±1.22 to 64.67±3.27 mg/dl, 3 h after oral administration of the extract (P

The hypoglycemic effect of ethanolic extract of Casearia esculenta was investigated on alloxan induced diabetic rats. The blood glucose levels were measured at 0, 1, 2 and 3 h after the treatment. The ethanolic extract of C. esculenta (250 mg/kg) reduced the blood glucose of normal rat from 85.50±1.22 to 64.67±3.27 mg/dl, 3 h after oral administration of the extract (P

Our aim was to clarify the effect of a somatostatin analogue (octreotide) on glucose flux in conscious dogs. We monitored the effects with catheters in the portal vein, hepatic vein and femoral artery and Doppler flow probes on the portal vein and hepatic artery before and after oral glucose administration. A significant increase of portal vein plasma flow after oral glucose was completely supp...

Measuring insulin sensitivity during the physiological milieu of oral glucose perturbation, e.g., a meal or an oral glucose tolerance test, would be extremely valuable but difficult since the rate of appearance of absorbed glucose is unknown. The reference method is a tracer two-step one: first, the rate of appearance of glucose (R(a meal)(ref)) is reconstructed by employing the tracer-to-trace...

BACKGROUND The Canadian and American Diabetes Associations recommend the use of an oral glucose tolerance test to screen for abnormal glucose tolerance among women with polycystic ovary syndrome when their fasting plasma glucose level is 5.7 mmol/L or more (Canadian guideline) and 5.6 mmol/L or more (American). Our objective was to determine the predictive value of 5.6 mmol/L as a fasting plasm...

With the rising prevalence of diabetes mellitus around world, researchers have been searching for a new treatment option that is both more effective and safer than chemotherapy. This study evaluated antidiabetic activities aqueous extracts Eclipta prostrataL. in streptozotocin (STZ)-induced diabetic rats. The rats were randomized into six groups: Normal control, STZ-induced (50 mg/kg), STZ + EP...

Sodium-glucose cotransporter 2 (SGLT2) is the major, and SGLT1 the minor, transporter responsible for renal glucose reabsorption. Increasing urinary glucose excretion (UGE) by selectively inhibiting SGLT2 improves glycemic control in diabetic patients. We generated Sglt1 and Sglt2 knockout (KO) mice, Sglt1/Sglt2 double-KO (DKO) mice, and wild-type (WT) littermates to study their relative glycem...

OBJECTIVE To compare the effect of oral glucose given with or without facilitated tucking (FT), versus placebo (water) to facilitate image acquisition during a targeted neonatal echocardiography (TNE). DESIGN Factorial, double blind, randomized controlled trial. SETTING Tertiary neonatal intensive care unit (NICU). PATIENTS Infants born between 26 and 42 weeks of gestation (GA). INTERVE...

Several studies have demonstrated that oral glucose tolerance is impaired in the immediate postexercise period. A double-tracer technique was used to examine glucose kinetics during a 2-h oral glucose (75 g) tolerance test (OGTT) 30 min after exercise (Ex, 55 min at 71 +/- 2% of peak O(2) uptake) and 24 h after exercise (Rest) in endurance-trained men. The area under the plasma glucose curve wa...