Objectives: This study aimed to investigate the acute oral toxicity of 77 herbal formulas and performed in male female Sprague-Dawley (SD) rats as per guidelines mentioned Ministry Food Drug Safety.Methods: Each sex SD rat were administered a single dose (2000 or 5000 mg/kg) via gavage; control group received vehicle only. After administration, mortality, clinical signs, gross findings, body we...

The efficacy of enrofloxacin (ENRO) was evaluated against multidrug-resistant avian pathogenic Escherichia coli correlating the minimum inhibitory concentrations (MIC) of 235 E. coli field strains with its pharmacokinetics (PK) in 50 healthy turkeys (5 groups) with a PK/pharmacodynamic approach. The treatments were as follows: a) single oral gavage and b) single subcutaneous (SC) treatment at t...

The aims of this research was to investigate effect alpha-tocopherol on spermatozoa death in form apoptosis and necrosis rats (Rattus norvegicus) exposed 2,3,7,8- tetrachlorodibenzo-p-dioxin. Male were administered TCDD experimental groups. Five groups a combination alpha- tocopherol designed as follows; 0.5 ml corn oil (control negative group, K-), 700 ng/kg/d (treatment control), 77 (Group P1...

Paraphenylenediamine (PPD) is a chemical product used in hair dye preparations and temporary tattoos to fasten the dyeing process intensify its results. PPD can evoke local and/or systemic toxic effects either when utilized topically, inhaled or ingested. The aim of this study was evaluate on liver adult female albino rats. Thirty-two rats were divided into 3 groups. Group I (control group) 16 ...

objective(s): carbon nanotubes have unique mechanical, electrical, and thermal properties, with potential different applications in nanomedicine, electronics, and other industries. these new applications of carbon nanotubes in different industries lead to the increased exposure risk of nanomaterials to human. up to now, all aspects of carbon nanotubes toxicity are not completely clear following...

Respiratory symptoms with rotavirus shedding in nasopharyngeal secretions have been reported in children with and without gastrointestinal symptoms (Zheng et al., 1991, J. Med. Virol. 34:29-37). To investigate if attenuated and virulent human rotavirus (HRV) strains cause upper respiratory tract infections or viremia in gnotobiotic pigs, we inoculated them with attenuated or virulent HRV intran...

Decursin and decursinol angelate are the major components in the alcoholic extract of the root of Angelica gigas Nakai. Our previous work convincingly demonstrated that both decursin and decursinol angelate were rapidly converted to decursinol in mice after administration by either oral gavage or i. p. injection. In the current study, we compared for the first time the plasma profiles of decurs...