The aim of this study is to prepare fluvastatin nanostructured lipid carriers (FLV-NLCs) in order to find an innovative way to alleviate FLV-associated disadvantages. The limitations include poor solubility and extensive first-pass metabolism, resulting in low (30%) bioavailability and short elimination half-life (1-3 hours). FLV-NLCs were prepared by hot emulsification-ultrasonication method. ...

This paper is motivated by the growing importance of better understanding of the phenomena and consequences of high-intensity energetic particle beam interactions with accelerator, generic target, and detector components. It reviews the principal physical processes of fast-particle interactions with matter, effects in materials under irradiation, materials response, related to component lifetim...

The distribution information of game maps is highly relevant to the execution efficiency of path searching and the degree of game difficulty. This paper analyzes the relationship between the pathfinding performance and the obstacles distribution in maps from two aspects, pathfinding algorithm design and game’s map design respectively. A hierarchical pathfinding algorithm called CDHPA* is propos...

The influence of water-to-cement mass ratio (w/c) on early-age properties of cementbased materials is investigated using a variety of experimental techniques. Properties that are critical to the early-age performance of these materials are tested, including heat release, semiadiabatic temperature, setting time, autogenous deformation, and strength development. Measurements of these properties u...