background: the aim of this study was to propose a new stochastic model to study the time course of ethanol elimination in human bodies. methods: the times and amount of alcohol ingested are assumed to be random in controllable intervals. constant elimination rate follows zero order kinetics and is replaced by first order kinetics when the effects of alcohol increase due to alcohol ingestion. s...

579 Background: 5-Fluorouracil (5-FU) remains the cornerstone of colorectal cancer (CRC) therapy and its dosing is based on body surface area (BSA). Although convenient, BSA dosing disregards factors that impact 5-FU PK such as genotype, age, gender, etc. Thus, patients receiving the same BSA based dose show a wide range of 5-FU plasma levels (measured as AUC in mg·h/L), resulting in ineffectiv...

Phage-therapy is a promising alternative against pathogenic, multiple drug resistant bacteria. In this work we propose an algorithm to determine the optimal bacteriophage dose able to minimize a population of Pseudomonas aeruginosa. Reverse engineering was used to determine the kinetic parameters; subsequently, a bi-level optimization platform was implemented for a model based on evolutionary p...

A new quantitative index is proposed to assign a numerical value that reflects the compromise between the therapeutic and side effects during treatment of AIDS using drugs that are active against HIV. The model considers that the clinical conditions are related to the values of CD4T cell counts and viral load. The therapeutic effect is associated with increase in the CD4T cell counts, while the...

This investigation was carried out to determine the effects of gamma radiation on germination characteristics gladiolus corms. experiment conducted through a factorial design in randomized complete block with three replications. Two factors included cultivars (Red Advance, White Prosperity, Amsterdam, and Rose Supreme) doses (0, 15, 25, 35, 45, 55, 65, 75 Gy). The results showed that corm weigh...

We review evidence from randomized, placebo-controlled studies of patients with schizophrenia or schizoaffective disorder, which compared 2 or more doses of an antipsychotic to calculate the dose-response curve for each first-generation (typical) antipsychotic (FGA) or second-generation (atypical) antipsychotic (SGA) and as a group (based on dose equivalence). We identified the near-maximal eff...