PURPOSE To describe the phenotype using electroretinography and optical coherence tomography (OCT) in members of two families with different mutations in RDS. METHODS DNA was extracted from blood samples and used for mutation screening by denaturing gradient gel electrophoresis (DGGE) and nucleotide sequencing of RDS exons. Patients were examined with clinical evaluation, full-field electrore...

Doppler optical coherence tomography (DOCT) is a valuable tool for depth-resolved flow measurements in tissue. However, DOCT is insensitive to flow in the direction normal to the imaging beam and requires knowledge of the phase of the demodulated signal. We present an alternative method of extracting flow information, using speckle of conventional amplitude optical coherence tomography images. ...

t i o e t t BJECTIVE: The purpose of this study was to use igh-speed optical coherence tomography (OCT) o obtain cross-sectional images of the rat cochlea. TUDY DESIGN AND METHODS: The cochleae of pragueDawley rats were imaged within 2 to 4 ours after death. Specimens were prepared by emoving the bulla to expose the mesotympanum; ome images were obtained in intact temporal ones removed from the...

Citation: Tan O, Konduru R, Zhang X, Sadda SR, Huang D. Dual-angle protocol for Doppler optical coherence tomography to improve retinal blood flow measurement. Tran Vis Sci Tech. 2014;3(4):6, http:// tvstjournal.org/doi/full/10.1167/tvst. 3.4.6, doi:10.1167/tvst.3.4.6 Purpose: To compare the performance of two different multiple-scan protocols for total retinal blood flow (TRBF) measurement usi...

We demonstrate how optical coherence imaging techniques can detect intrinsic scattering changes that occur during action potentials in single neurons. Using optical coherence tomography (OCT), an increase in scattering intensity from neurons in the abdominal ganglion of Aplysia californica is observed following electrical stimulation of the connective nerve. In addition, optical coherence micro...

Aim – To compare the results of optic disc analysis using optical coherence tomography, fundus photography and stereoscopic biomicroscopy. Materials & Methods – A comparative, observational case series and interobserver variability study in which 2 groups of patients were analysed by all the 3 methods. One group had primary open angle glaucoma patients and the other group were patients undergoi...

Hand-held OCT systems that offer physicians greater freedom to access imaging sites of interest could be useful for many clinical applications. In this study, by incorporating the theoretical speckle model into the decorrelation function, we have explicitly correlated the crosscorrelation coefficient to the lateral displacement between adjacent A-scans. We used this model to develop and study a...

Objective To evaluate the efficacy of methods that use deep learning (DL) for the automatic fine-grained segmentation of optical coherence tomography (OCT) images of the retina.

We present a parametric optical coherence tomography (OCT) technique to improve contrast between malignant and healthy non-neoplastic tissue. The technique incorporates a fully automated method to extract tissue attenuation characteristics. Results are represented visually as a parametric en face image, where the parameter used for contrast is indicative of the relative optical attenuation coef...