The aim of the present study was to examine the role of the expression of transient axonal glycoprotein-1 (TAG1)/precursor protein (APP) signaling pathway in the proliferation and differentiation of glioma stem cells. A glioma cell line (U373) was used as well as fluorescence quantitative PCR, western blot analysis, and enzyme-linked immunosorbent assay (ELISA), to examine the role of the expre...

BACKGROUND AND PURPOSE Despite the benign histology of optic pathway glioma (OPG) (low-grade astrocytoma), its biological behavior is unpredictable, and it is unclear whether specific morphologic or anatomic patterns may be predictive of prognosis. It is also unclear whether OPG associated with neurofibromatosis (NF) is a distinct entity from non-NF-OPG. Our purpose was to describe the MR imagi...

A study is reported of the effect of early visual experience on the development of auditory space perception. The spatial hearing of thirty-five children with visual disabilities (twenty-two with congenital total blindness) was compared with that of eighteen sighted children and seventeen sighted adults. The tests provided a comprehensive assessment of spatial-hearing ability, including psychop...

Behavioural findings have led to proposals that difficulties in attention and concentration in depression may have their roots in fundamental inhibitory impairments for irrelevant information. These impairments may be associated with reduced capacity to actively maintain relevant information to facilitate goal-directed behaviour. In light of mixed data from behavioural studies, the current stud...

Visual clutter concerns designers of user interfaces and information visualizations. This should not surprise visual perception researchers because excess and/or disorganized display items can cause crowding, masking, decreased recognition performance due to occlusion, greater difficulty at both segmenting a scene and performing visual search, and so on. Given a reliable measure of the visual c...

During the past decade it became evident that anaerobic cultivation-based approaches provides an incomplete picture of the microbial diversity in the GI tract, since at present only a minority of microbes can be obtained in culture. The application of molecular, mainly 16S ribosomal RNA (rRNA)-based approaches enables researchers to bypass the cultivation step and has proven its usefulness in s...

BACKGROUND Non-optic gliomas occur in 5% of children with NF1, but little is known about these tumours in adults. We aimed to investigate progression, spontaneous regression and the natural history of non-optic gliomas in adults and compare these findings to the results found in children. RESULTS One thousand seven hundred twenty-two brain MRI scans of 562 unselected individuals with NF1 were...

Introduction: We aimed to dosimetrically compare three-dimensional conformal radiotherapy (3D-CRT) and volumetric modulated arc therapy (VMAT) in terms of planning target volume (PTV) coverage, organ at risk (OAR) sparing, and conformity index (CI). Material and Methods: Planning data of 26 high grade glioma (HGG) patients were used. Prescrib...

A comprehensive approach for describing the functional and behavioral aspects of communicative actions, e.g. facial, manual, and vocal tract actions, has been established for face-to-face-communication (Cogn Process 11:187-205, 2010). Within the speech domain, this approach will now be extended in two ways: (i) by introducing level actions such as turn, breath group, phrase, stress group, sylla...

The ability of Candida albicans to cause disease is associated with its capacity to undergo morphological transition between yeast and filamentous forms, but the role of morphology in colonization and dissemination from the gastrointestinal (GI) tract remains poorly defined. To explore this, we made use of wild-type and morphological mutants of C. albicans in an established model of GI tract co...