Objective: To assess visual acuity and contrast sensitivity in various form of Optic neuritis patients. Study Design Settings: It was a hospital based cross sectional study conducted eye department Teaching hospital, University Lahore Pakistan. Total duration the 4 months from January 2022-April 2022. Methods: A total 32 patients were included study. Purposive sampling technique adopted for sam...

Optic neuritis is a clinical syndrome resulting from inflammation, demyelination, or infection of the optic nerve. Its diagnosis and treatment are complicated. In 1884, Nettleship first reported 28 cases of optic neuritis whose clinical symptoms have been accepted up to the present without any change. On the other hand, the development of diagnostic procedures and steroid therapy have also alte...

ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Fijałkowska-Cmokowicz G, Filipek E, Lenik M, Tronina A. Evaluation of the ganglion cell and inner plexiform layer in children with optic neuritis. Klinika Oczna / Acta Ophthalmologica Polonica. 2023. doi:10.5114/ko.2023.124699. APA Fijałkowska-Cmokowicz, G., Filipek, E., Lenik, M., & Tronina, (2023). https://doi.o...

Extensive optic nerve demyelinating lesions on magnetic resonance imaging (MRI) in adults could indicate a diagnosis other than multiple sclerosis with worse prognosis such as neuromyelitis optica. We report the frequency of longitudinally extensive lesions in children with first events of optic neuritis. Subjects had brain or orbit MRI within 3 months of onset and were evaluated at the Univers...

Longitudinal studies have shown that brain white matter lesions are strong predictors of the conversion of unilateral optic neuritis to multiple sclerosis (MS) in Caucasian populations. Consequently brain MRI criteria have been developed to improve the prediction of the development of clinically definite multiple sclerosis (CDMS). In Asian populations, optic neuritis may be the first sign of cl...

OBJECTIVE To determine if adenoviral-mediated transfer of the gene for catalase (CAT), the reactive oxygen species scavenger, suppresses experimental optic neuritis. CLINICAL RELEVANCE Gene therapy with CAT delivered by an adeno-associated viral vector was previously shown to suppress experimental optic neuritis. Because the transduction of protein expression with recombinant adeno-associated...

Optic neuritis is an inflammation of the optic nerve and may be related to different systemic conditions. The clinical presentation of this pathology usually includes sudden loss of visual acuity (VA) which may be unilateral or bilateral, visual field restriction, pain with eye movements, dyschromatopsia, a relative afferent pupillary defect and optic disk swelling. Optic neuritis in children h...

We measured contrast sensitivity by means of Arden grating plates in 41 eyes with acute optic neuritis and in 51 eyes with resolved optic neuritis. The scores were abnormal in 93% of eyes in the acute phase and 78% in the resolved phase irrespective of visual acuity. Even when acuity improved to 6/7.5 or better with resolution of the neuritis, 67% of eyes still showed abnormal contrast sensitiv...

INTRODUCTION Common variable immunodeficiency encompasses a group of heterogeneous conditions linked by a lack of immunoglobulin production and primary antibody failure. Although primary immunodeficiencies are typically characterized by recurrent infections, autoimmune manifestations have increasingly been recognized. Neurological complications are extremely rare and to the best of our knowledg...