conclusion the study evaluated the biomechanical properties of the on and peripapillary structures in vivo with swe in glaucoma. we observed stiffer on and peripapillary tissue in glaucomatous eyes, indicating that swe claims new perspectives in the evaluation of on and peripapillary structures in glaucoma disease. background primary open-angle glaucoma is a multifactorial serious disease chara...

PURPOSE The defining feature of glaucoma is excavation of the optic nerve head; however, the mechanism of this loss of tissue is not well understood. We recently discovered a copy number variation upstream of matrix metalloproteinase 19 (MMP19) in a large, autosomal dominant pedigree with a congenital malformation of the optic disc called cavitary optic disc anomaly (CODA). Patients with CODA h...

Purpose We determined whether the chronic lack of optic nerve myelination and subsequent axon loss is associated with optical coherence tomography (OCT) changes in the retinal nerve fiber layer (RNFL), and whether this models what occurs in multiple sclerosis (MS) and confers its use as a surrogate marker for axon degeneration. Methods Using an animal model of Pelizaeus-Merzbacher disease (sh...

PURPOSE Von Hippel-Lindau (VHL) disease is a hereditary cancer syndrome expressed in multiple organs caused by germline alterations of the VHL gene. We have shown VHL deletion in the "stromal" cells of retinal angiomas. The VHL protein-associated complex is a primary ubiquitin ligase for the ubiquitination of hypoxia-inducible factor (HIF). This study examines VHL and ubiquitin expression in op...

Mechanisms of Progression in Glaucoma Glaucoma is a neurodegenerative disease characterised by progressive loss of retinal ganglion cells (RGCs) over time with associated progressive visual field loss. Elevated intraocular pressure is the strongest risk factor for glaucoma, but the mechanisms by which damage occurs in the disease remain incompletely understood; however, a number of important pr...

BACKGROUND Glial fibrillary acidic protein (GFAP) is a specific intermediate filament of the cytoskeleton of the astrocyte and may be used as a specific marker for astrocytic damage. It is detectable in the cerebrospinal fluid following a relapse caused by Multiple Sclerosis (MS) and Neuromyelitis Optica (NMO) spectrum disease. Higher levels are found following an NMO-related relapse. It is not...

Objective. To evaluate a new method of measuring hemoglobin (Hb) levels and quantifying the color changes in the optic nerve head of Parkinson's disease (PD) patients. We also compared differences in retinal nerve fiber layer (RNFL) thicknesses obtained using spectral domain optical coherence tomography (OCT) device between PD group and healthy group. Methods. One hundred and fifty-five PD pati...

PURPOSE To assess the symmetry of optic nerve head parameters measured by the Heidelberg Retina Tomograph 3 (HRT 3) between fellow eyes in a normal elderly population. DESIGN Cross-sectional population-based study. METHODS Participants of the Blue Mountains Eye Study 10-year follow-up who did not have optic disc disease, including glaucoma, were included. Optic nerve head parameters measure...

The PhD dissertation was carried out at the Eye Pathology Institute, University of Copenhagen, and the Department of Ophthalmology, Rigshospitalet, Copenhagen University Hospital. The aim was to investigate tumours of the optic nerve in a known population. Therefore, we studied all surgically removed tumours of the optic nerve in Denmark during a study period of 25 years. Furthermore, in order ...

PURPOSE Macular schisis or detachment is frequently observed in eyes with optic pits or colobomas. Although spontaneous resolution of the maculopathy has been reported, concurrent changes in the optic nerve coloboma have not. We report three cases of atypical optic nerve colobomas in which dynamic optic nerve changes coincide with the development and subsequent resolution of the associated macu...