نتایج جستجو برای: opioid substitution therapies

تعداد نتایج: 182726  

Journal: :BMC Psychiatry 2007
Bernhard W Müller Michael Specka Nicolai Steinchen Dieter Zerbin Ernst Lodemann Thomas Finkbeiner Norbert Scherbaum

BACKGROUND The P300 component of the auditory evoked potential is an indicator of attention dependent target processing. Only a few studies have assessed cognitive function in substituted opiate addicts by means of evoked potential recordings. In addition, P300 data suggest that chronic nicotine use reduces P300 amplitudes. While nicotine and opiate effects combine in addicted subjects, here we...

Journal: :The Journal of pharmacology and experimental therapeutics 2003
Vipa Chaipatikul Horace H Loh P Y Law

The mechanism for the differential regulation of the mu-opioid receptor by agonists is investigated by identifying the receptor domains used to define the relative efficacies of three mu-opioid receptor-selective agonists: [D-Ala2,N-Me-Phe4,Gly5-ol]-enkephalin (DAMGO), morphine, and [N-MePhe3,D-Pro4]-morphiceptin (PL017) to inhibit forskolin-stimulated intracellular cAMP production in human emb...

Journal: :Canadian Pharmacists Journal / Revue des Pharmaciens du Canada 2019

2014
Claudia Friesen Inis Hormann Mareike Roscher Iduna Fichtner Andreas Alt Ralf Hilger Klaus-Michael Debatin Erich Miltner

Glioblastoma are the most frequent and malignant human brain tumors, having a very poor prognosis. The enhanced radio- and chemoresistance of glioblastoma and the glioblastoma stem cells might be the main reason why conventional therapies fail. The second messenger cyclic AMP (cAMP) controls cell proliferation, differentiation, and apoptosis. Downregulation of cAMP sensitizes tumor cells for an...

2014
Sarah Larney Natasa Gisev Michael Farrell Timothy Dobbins Lucinda Burns Amy Gibson Jo Kimber Louisa Degenhardt

OBJECTIVES To describe deaths in prison among opioid-dependent people, and examine associations between receipt of opioid substitution therapy (OST) and risk of death in prison. DESIGN Retrospective cohort study. SETTING Adult prisons in New South Wales (NSW), Australia. PARTICIPANTS 16 715 opioid-dependent people who were received to prison between 2000 and 2012. INTERVENTIONS Opioid s...

Journal: :Journal of pain and symptom management 2009
Helena Knotkova Perry G Fine Russell K Portenoy

Opioid rotation refers to a switch from one opioid to another in an effort to improve the response to analgesic therapy or reduce adverse effects. It is a common method to address the problem of poor opioid responsiveness despite optimal dose titration. Guidelines for opioid rotation are empirical and begin with the selection of a safe and reasonably effective starting dose for the new opioid, ...

2011
Paolo Mannelli Kathleen S Peindl Li-Tzy Wu

PURPOSE: Opioid dependence (OD) is a serious and growing clinical condition with increasing social costs that requires expanding treatment beyond opioid agonist substitution. The opioid antagonist naltrexone has displayed a remarkable association of theoretical effectiveness and poor clinical utility in treating OD due to noncompliant behavior and low acceptability among patients, only partly m...

Journal: :Drug and alcohol dependence 2015
Gerardo Gonzalez Gregory DiGirolamo Mauricio Romero-Gonzalez David Smelson Douglas Ziedonis Monika Kolodziej

BACKGROUND Opioid use disorders are considered a serious public health problem among young adults. Current treatment is limited to long-term opioid substitution therapy, with high relapse rates after discontinuation. This study evaluated the co-administration of memantine to brief buprenorphine pharmacotherapy as a treatment alternative. METHODS 13-week double-blind placebo-controlled trial e...

Journal: :Circulation 2001
P Kienbaum T Heuter M C Michel N Scherbaum M Gastpar J Peters

BACKGROUND Opioid-addicted patients undergoing detoxification provide a unique opportunity to assess the effects of chronic opioid receptor stimulation on the sympathetic nervous system. We tested the hypothesis that chronic oral methadone intake decreases resting efferent sympathetic nerve activity to muscle (MSA). Furthermore, we assessed whether this effect is reversed by mu-opioid receptor ...

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