BACKGROUND There have been inconsistent findings on the association between current drug use and HIV disease progression and virologic suppression. Drug use was often measured using self-report of historical use. Objective measurement of current drug use is preferred. METHODS In this cross-sectional study, we assessed drug use through Computer-Assisted Self Interviews (CASI) and point-of-care...

Opiates are still the most effective and widely used treatments for acute and chronic pain. However, the problems associated with morphine and other standard opioid analgesics severely limit their effectiveness in the clinic. PPL-101 and PPL-103 derived from morphine and morphinan ring systems contain a chiral N-substituent, which confers it with a unique combination of high-binding affinities ...

BACKGROUND Doctor-shopping may reflect unmet patient needs and places a significant burden on health resources; however little is known about its underlying reasons and how it relates to mental illness and its recognition in an open access fee-for-service setting. METHODS In 2003-2004, consecutive patients of 46 French general practitioners (GPs), completed in the waiting room the self-report...

Previous research has evidenced that in different institutional settings professionals are cautious when responding to clients’ indirect complaints and tend to avoid siding either with the clients/ complainants or the complained-of absent parties. In this article we use the method of Conversation Analysis to explore professional responses to clients’ indirect complaints in the context of a Ther...

We estimate the impacts of the Earned Income Tax Credit on labor supply using local variation in knowledge about the EITC schedule. We proxy for EITC knowledge in a ZIP code with the fraction of individuals who manipulate reported self-employment income to maximize their EITC refund. This measure varies significantly across areas. We exploit changes in EITC eligibility at the birth of a child t...

American Indians are the most under-represented minority group across all levels of education. The present study investigates sociocultural, psychological, and nontraditional academic factors that influence American Indian students’ decisions to pursue higher education (e.g., vocational training, college). Nineteen American Indians with previous academic difficulties completed several self-repo...

Exogenous cholecystokinin selectively antagonizes opiate analgesia, which suggests that endogenous cholecystokinin may act physiologically as an opiate antagonist and may play a role in opiate tolerance. The use of the selective cholecystokinin antagonist proglumide provided a test of these hypotheses in rats that were either inexperienced with or tolerant to opiates. Proglumide potentiated ana...

BACKGROUND The field of serious games for people with dementia (PwD) is mostly driven by game-design principals typically applied to games created by and for younger individuals. Little has been done developing serious games to help PwD maintain cognition and to support functionality. OBJECTIVES We aimed to create a theory-based serious game for PwD, with input from a multi-disciplinary team ...

This article reports the results of a survey of Chief Information Officers (CIOs) from Fortune 1000 companies on their perceptions of the critical success factors in Enterprise Resource Planning (ERP) implementation. Through a review of the literature, 11 critical success factors were identified , with underlying subfactors, for successful ERP implementation. The degree of criticality of each o...

OBJECTIVES Poor adherence to anti-hypertensive medication severely compromises the effectiveness of treatment. The aim of this study was to determine the factors that are associated with poor adherence in a sample of hypertensive patients in Nsukka, Nigeria. METHODS The study employed a cross sectional, household survey to identify cases of hypertension in Nsukka. Adherence to antihypertensiv...