We describe a method for determination of barbiturates, amphetamines, opiates, and methadone by the “enzyme multiplied immunoassay technique” (EMIT) applied to the centrifugal analyzer. This method gives results that agree well (92% for barbiturates, 97% for opiates, 94% for methadone, and 96% for amphetamines) with those obtained by the same technique with the SyvaGilford EMIT instrumentation,...

INTRODUCTION This research was to follow characteristics of breakthrough pain caused by cancer (BTcP) and other most common sympthoms (ESAS) at patients in advanced stage of cancer disease in palliative care. PATIENTS AND METHODS Prospective study included 433 patients which were treated in Palliative Care Centre in UKC Tuzla, Bosnia and Herzegovina. Group 1 was consisted of 353 patients whos...

Opioid peptides, and especially the dynorphins, have been localized to several circuits in the CA3 hippocampal region, yet electrophysiological studies often find mixed effects of opiates on the excitability of CA3 neurons. Reasoning that these mixed effects might involve voltage-dependent actions, we tested the effect of several opiates on CA3 pyramidal neurons using single-electrode voltage-c...

objective(s) opioid abuse is still remained a major mental health problem, a criminal legal issue and may cause ischemic brain changes including stroke and brain edema. in the present study, we investigated whether spontaneously withdrawal syndrome might affect stroke outcomes. materials and methods addiction was induced by progressive incremental doses of morphine over 7 days. behavioral signs...

Abstract Introduction Post-operative pain relief commonly involves opiates. Rising concerns about misuse has increased scrutiny of prescribing practices. In the UK, 12.5% prescriptions are for US, Department Health and Human Services declared an epidemic opiate misuse. We aimed to evaluate practices post-operatively, within a UK teaching hospital, establish risk prolonged use. Method A pan-spec...