Immunohistochemistry of formalin-fixed human Alzheimer's disease (AD) tissue using an anti-tau antibody (Tau-1) reveals staining of neurofibrillary tangles (NFTs) and neuritic plaques (NPs), whereas normal axonal staining is less apparent. In this study, we used a combined biochemical and histochemical approach to assess effects of formalin on immunoreactivity of AD tau. Nitrocellulose blots we...

Tau is a microtubule-associated protein which regulates the assembly and stability of microtubules in the axons of neurons. Tau is also a major component of neurofibrillary tangles (NFTs), a pathological hallmark in Alzheimer's disease (AD). A characteristic of AD tau is hyperphosphorylation with more than 40 phosphorylation sites. Aggregates of hyperphosphorylated tau are also found in other n...

in this paper, we propose and analyze an efficient matrix methodbased on bell polynomials for numerically solving nonlinear fredholm- volterraintegral equations. for this aim, first we calculate operational matrix of integration and product based on bell polynomials. by using these matrices, nonlinearfredholm-volterra integral equations reduce to the system of nonlinear algebraicequations which...

Aims. We obtain accurate estimates for the individual masses of the components of the tight binary system T Tau S to settle the ongoing debate on the nature of T Tau Sa, a so-called infrared companion. Methods. We take advantage of the fact that T Tau S belongs to a triple system composed of two hierarchical orbits to simultaneously analyze the motion of T Tau Sb in the rest frames of T Tau Sa ...

Cost-effective and feasible methods for early diagnosis of Alzheimer's disease (AD) are needed. We present two methods to measure AD-related biomarkers simultaneously from one nasal smear for the purpose of diagnosing AD. Japanese men and women aged 63-85 years old were recruited in 2015-2016 for this case-control study. A total of 25 AD cases and 25 controls (22 men and 28 women) participated ...

‎In this paper‎, ‎we define and study the notion of zero elements in topoframes; a topoframe is a pair‎ ‎$(L‎, ‎tau)$‎, ‎abbreviated $L_{ tau}$‎, ‎consisting of a frame $L$ and a‎ ‎subframe $ tau $ all of whose elements are complemented elements in‎ ‎$L$‎. ‎We show that‎ ‎the $f$-ring $ mathcal{R}(L_tau)$‎, ‎the set of $tau$-real continuous functions on $L$‎, ‎is uniformly complete‎. ‎Also‎, ‎t...

Left ventricular diastolic time constant, Tau, is the most established index to describe left ventricular diastolic function. However, the lack of a practical method for the measurement of Tau has been an uncomfortable reality which formerly kept all but a few researchers from making use of it. Recently, the non invasive calculation of Tau in an echo lab was accomplished through formulas develo...

The tau protein is a neuronal microtubule-associated protein. Apart of its physiological function-the binding to and stabilization of microtubules-tau is found in Alzheimer's disease brain as insoluble fibers, the so-called "paired helical filaments" (PHFs). Investigating the fundamentals of tau polymerization is indispensable for identifying inhibitory conditions or compounds preventing PHF fo...