Recent genomic studies have outlined a landscape of recurrent alterations within some subtypes of lymphoid cancer. Yet, the timing and cellular contexts during which these alterations occur (ie, the molecular ontogeny) remain poorly understood. Lymphoid malignancies offer an exceptional opportunity to delineate the ontogeny of somatic alterations, as lymphocyte differentiation absolutely requir...

The dopamine ontogeny hypothesis for schizophrenia proposes that transient dysregulation of the dopaminergic system during brain development increases the likelihood of this disorder in adulthood. To test this hypothesis in a high-throughput animal model, we have transiently manipulated dopamine signaling in the developing fruit fly Drosophila melanogaster and examined behavioral responsiveness...

Ecoimmunology conceptualizes the role of immunity in shaping life history a natural context. Within ecoimmunology, macroimmunology is framework that explains effects habitat and spatial differences on variation immune phenotypes across populations. these frameworks, ontogeny—the development system an individual span—has received little attention. Here, we investigated how ontogeny from birth un...

The progesterone receptor (PR) is transiently expressed in the rat cortex during development and its expression is initiated in the developmentally critical layer, the subplate. As subplate neurons pioneer thalamocortical and corticofugal connectivity, the expression of PR in this layer suggests an important function for PR in cortical development. Using immunocytochemistry for PR, the present ...

Readers will notice a new addition to this issue. The following article by Viktor Hamburger is the first of a series of general interest articles that the Editors plan to include in the Journal pages. Because of the backlog of primary research reports (see Society for Neuroscience Newsletter, Vol. 19, No. 2 (March/April), 1988, pp. 6-7), feature articles will appear only occasionally at first. ...

Gestures, hand movements that accompany speech, affect children's learning, memory, and thinking (e.g., Goldin-Meadow, 2003). However, it remains unknown how children distinguish gestures from other kinds of actions. In this study, 4- to 9-year-olds (n = 339) and adults (n = 50) described one of three scenes: (a) an actor moving objects, (b) an actor moving her hands in the presence of objects ...

Climate change is altering the phenology of many species and the timing of their interactions with other species, but the impacts of these phenological shifts on species interactions remain unclear. Classical approaches to the study of phenology have typically documented changes in the timing of single life-history events, while phenological shifts affect many interactions over entire life hist...

A characteristic feature of primate life histories is the prolonged period of postnatal development in which newborns depend on adults, especially their mothers, for nutrition, transport, and protection, and develop social skills that enable them to become fully integrated members of society. Many researchers have focused on the development of infant nonhuman primates, attempting to identify fa...

Foot skeletons of small (young) hadrosaurid dinosaurs were compared with those large (adult) hadrosaurids to assess the extent pedal shape change during ontogeny. juvenile also similar-sized adult, bipedal, non-hadrosaurian ornithischians which closer in size, investigate possibility that ontogeny would have been great enough for feet (and therefore footprints) young more similar small-bodied t...

This study presents the findings on influence of raspberry varieties species composition micromycetes in rhizosphere soil and vegetative organs plants organic production. The mycobiota Joan J Himbo-Top was analysed during plant ontogeny phytopathogenic microspecies leaves determined. It found that population is dominated by fungi: Septoria rubi, West, Botrytis cinerea, Pers, Aspergillus niger, ...