background : apolipoprotein e (apoe) gene encodes an important protein in reforming injuries of central nervous system (cns). it is assumed that various apoe alleles may be functionally different. the purpose of this study was to investigate the distribution of apoe genotypes in multiple sclerosis (ms) patients in a small cohort of iranians. methods : in this case-control study, blood samples o...

Ten patients with multiple sclerosis were found to have lived in close proximity in a Nova Scotia farming community of 150 people. All had drunk unpasteurized milk as children, were teetotallers, ate a high animal fat diet, and were well educated. Of greater interest was the observation that six of the ten cases were related in two family groups. The only time all patients lived in the communit...

Thirty patients suffering from multiple sclerosis have been compared with 30 patients suffering from other chronic neurological diseases. The degree of disability was similar in these two groups. The patients with multiple sclerosis had experienced more episodes of severe depression both before and after the onset of neurological symptoms. The possible reasons for these episodes are discussed a...

background:  multiple  sclerosis  (ms) is a  chronic inflammatory  demyelinating  and  neurodegenerative disease  of central  nervous  system  with unknown  causes. etiology of ms involves  both  genetic  and  environment factors.  the  interleukin  7   receptor   (il7r)   gene   is  a promising candidate  for ms, because its involvement in the autoimmunity, regulation of the t-cell homeostasis...

abstract background: fatigue is the most common and highly disabling symptom of multiple sclerosis (ms) that has negative effects on employment, the process of socialization, compliance with the disease, and other factors effective on activities of daily living. the usage of complementary and alternative medicine methods in ms patients is higher than in the general population. however, there is...

background: mesenchymal stem cells (mscs) with their potential to differentiate into mesodermal and non-mesodermal lineages have several immunomodulatory characteris-tics. these properties make them promising tools in cell and gene therapy. objective: to evaluate the potential therapeutic applications of autologous msc in improving clinical manifestations of ms patients. methods: ten patients w...

multiple sclerosis (ms) and migraine are two common neurological disorders affecting women more than men. sleep quality impairment has been reported in both diseases. the goal of this study was to compare sleep quality and depression between women with ms and migraine. seventy women with migraine and 75 women with ms were enrolled in this study. participants were asked to fill-out valid and rel...

none of the approved immunomodulatory drugs in adults multiple sclerosis (ms) patients have been officially approved for the pediatric patients and are currently used off-label in this population. in this study, we evaluated the effectiveness and tolerability of intramuscular interferon beta1-a (avonex®) and subcutaneously injected interferon beta1-b (betaferon®) in children with definite relap...

conclusions orem’s self-care model is significantly effective in reducing the fatigue of multiple sclerosis patients. objectives to determining the effect of orem’s self-care model on fatigue in multiple sclerosis patients. patients and methods this research involved a clinical trial. sixty-three multiple sclerosis patients at the vice-chancellor in treatment affairs of yasuj university of medi...