نتایج جستجو برای: one pot solvent free synthesis
تعداد نتایج: 2797739 فیلتر نتایج به سال:
An efficient and environmentally friendly procedure for one-pot synthesis of 13-acetyl-9-methyl-11-ox-8-oxa-10,12-diazatricyclo [7.3.1. ] trideca-2,4,6-triene from salicylaldehyde, acetylaceton and urea via Biginelli condensation and intramolecular Michael-addition by using magnesium bromide as an expensive and easily available catalyst under solvent-free condition is desired. The structural el...
Decatungstodivanadogermanic acid (H6GeW10V2O40.22H2O) was used as a green heterogeneous catalyst for the synthesis of 3,4-dihydropyrimidin-2-(1H)-ones from one-pot three-component cyclocondensation reaction of a β-ketoester, an aldehyde and urea/thiourea under solvent-free conditions is reported. This method provides an efficient and much improved modification of the original Biginelli reaction...
A Simple and environmentally friendly procedure for the one-pot multi-component synthesis of 3,4-dihydropyrimidin-2(1H)-one derivatives has been developed by one pot three component reaction of various aldehydes, β-dicarbonyl, and urea in the presence of catalytic amount of tris (trihexyltetradecylphosphonium) gadolinium hexachloride [P6,6,6,14]3 [GdCl6] as a solid acid catalyst without any ad...
an efficient synthesis of methyl 2-[2-(alkylimino)-4-oxo-3-phenyl-1,3-thiazolan-5-yliden]acetate derivatives via simple three-component reaction and one-pot reactions between isoquinoline, dimethyl acetylenedicarboxylate and n-phenylthiourea under solvent-free conditions without using any additional catalyst, is described. the mild reaction conditions and good yields and exhibit the synthetic a...
A zeolite-catalyzed, simple, one-pot, solvent-free, cost effective, and environmentally benign process for the synthesis of dihydropyrimidones is described. This reaction is scaleable to multigram scale and the catalyst is recyclable. This methodology has resulted in an efficient synthesis of monastrol, a potent inhibitor of kinesin Eg5.
To develop a new facile protocol for the synthesis of 2'-aminobenzothiazolo-arylmethyl-2-naphthol derivatives, N-bromosuccinimide (NBS) was used as an efficient catalyst for the one-pot synthesis of 2'-aminobenzothiazolo-arylmethyl-2-naphthols in excellent yields from β -naphthol (1 mmol), aromatic aldehydes (1 mmol), and 2-aminobenzothiazole (1 mmol) at 60°C under solvent-free conditions.
Silica boron sulfonic acid [SiO2–B(OSO3H)3] as an inexpensive, reusable, and Lewis and Brønsted acid catalyst was successfully synthesized, and used for the one-pot three-components synthesis of biologically active substituted Hantzsch 1,4-dihydropyridine derivatives in the absence of solvent at 90ºC. Silica boron sulfonic acid is attractive and efficient, because it plays in two role as a Lew...
phenytoine derivatives were synthesized , via the pinacol condensation with the reaction of 1,3- diphenyl- propane- 1,3- dione (benzyl) analogs with urea or thiourea in presence of slica gel and solid KOH as Solid phase catalyst in the mortar / pestle at room temperatures. The reaction was completed at short reaction times (approximately 15min) and pure products were obtained with high yiel...
The chemistry of 2-oxo-1,2,3,4-tetrahydropyrimidines began to develop toward the end of 1893 year, when the first representatives of this class compounds were reported by P. Biginelli. Despite prior reports of several really effective catalytic and non-catalytic approaches towards Biginelli-type products, an overwhelming number of new catalysts for the Biginelli reaction have been recently publ...
A simple, fast, efficient and environmentally friendly method for synthesis of benzimidazole and its 2-alkyl, aryl and heteroaryl substituted derivatives was developed using zeolite HY. Two component cyclolcondensation of 1,2-phenylenediamine (o-phenylenediamine) and commercially available carboxylic acids catalyzed by zeolite HY without any solvent, under microwave irradiation led to formation...
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