Advances in sarcoma treatment are largely based on investigator-initiated, multicentric and interdisciplinary clinical trials. The EU’s Good Clinical Practice Directive 2001/20/EC, effective since 2004, was meant to harmonize the conditions for clinical trials across Europe, but, instead, the challenge of initiating and running multinational, noncommercial clinical trials has become greater tha...

no 1: Technical challenges of fast volumetric rescanning O. Actis, D. Meer, A. Mayor, G. Klimpki, S. Psoroulas, D.C. Weber For pencil beam scanning the most studied method to mitigate the dose delivery uncertainties due to the organ motion is rescanning. Achieving an optimal treatment for a moving target by volumetric rescanning, where the whole tumour volume is scanned multiple times, requires...

External electric fields were used to amplify thermal fluctuations at the interface between two thin liquid films. Similar to the results shown previously for the enhancement of fluctuations at the polymer/air interface, interfacial fluctuations having a well-defined wavelength were enhanced with a characteristic growth rate. A simple theoretical framework to describe the experimental observati...

Business schools are putting more emphasis on the improvement of teaching and learning methods to better prepare their graduates and meet the industry demands. This improvement has been sought through the use of face to face teaching approach blended with industry projects and experiential exercises. This study reports on a similar effort initiated in teaching the international marketing course...

The issue of hormone therapy for transgender inmates, while seemingly limited in importance, is one that involves issues of greater importance for the transgender community. The greatest issue at the heart of the matter is the legal argument that is traditionally used to gain access to hormone therapy: the Eighth Amendment. The Eighth Amendment prohibits deliberate indifference to the medical n...

Methods A 3-month pilot was performed offering massage therapy to postoperative breast surgical patients. A certified massage therapist approached patients the day after surgery. Massage duration was determined by discussion between the therapist and patient. Massage was offered at a fee of $1/minute and billed through the institutional billing system. Pain, anxiety and tension levels were docu...

Potential promoters in the genome of Escherichia coli were searched by pattern recognition software PlatProm and classified on the basis of positions relative to gene borders. Beside the expected promoters located in front of the coding sequences we found a considerable amount of intragenic promoter-like signals with a putative ability to drive either antisense or alternative transcription and ...

The objective of this study was to examine the impact of a brief mindfulness intervention on the constructs of mindfulness and thought suppression with undergraduates. The brief mindfulness intervention was comprised of both instructive and hands-on exercises that were manualized in a protocol. A randomized experimental design was utilized in this study. The independent variable (treatment) was...