Besides their central role in ATP synthesis and oxidative metabolism of nutrients, mitochondria contribute to intracellular Ca homeostasis and generation of reactive oxygen species (ROS) and are determinant for both cell survival and cell death. Important for any cell type, these functions are crucial for cardiac myocytes. Mitochondrial processes are highly compartmentalized because of the exis...

Tail-anchored (TA) proteins are a unique class of functionally diverse membrane proteins defined by their single C-terminal membrane-spanning domain and their ability to insert post-translationally into specific organelles with an Ncytoplasm-Corganelle interior orientation. The molecular mechanisms by which TA proteins are sorted to the proper organelles are not well-understood. Herein we prese...

Background & aimsHuman milk is the gold standard for infant nutrition. Preterm infants whose mothers are unable to provide sufficient own mother's (OMM), receive pasteurized donor human (DHM). We studied metabolic signatures of OMM and DHM their effect on interplay developing microbiota infant's metabolism.MethodsMetabolic fingerprinting as well urine was performed using liquid chromatography–m...

The Committee on Nutrition of the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition aims to document the existing evidence of the benefits and common concerns deriving from the use of donor human milk (DHM) in preterm infants. The comment also outlines gaps in knowledge and gives recommendations for practice and suggestions for future research directions. Protection aga...

Radical S-adenosylmethionine (rSAM) enzymes use a 5'-deoxyadensyl 5'-radical to methylate a wide array of diverse substrates including proteins, lipids and nucleic acids. One such enzyme, Elongator protein-3 (TgElp3), is an essential protein in Toxoplasma gondii, a protozoan parasite that can cause life-threatening opportunistic disease. Unlike Elp3 homologues which are present in all domains o...

PURPOSE Choroidal malignant melanomas (CMMs) are the most common primary intraocular tumors in adult humans. Although radiotherapy is commonly used to treat the melanomas, the therapeutic effects are unpredictable. The purpose of this study was to search for a gene(s) that can predict the success of radiotherapy for CMMs. METHODS The cell lines 92-1, OCM-1, and OMM-1 were established from pat...

Serine/threonine phosphatase 2A (PP2A) consists of an AC core dimer composed of catalytic (C), structural (A) subunits complexed to a variable regulatory subunit derived from three gene families (B, B’, B”). My dissertation work characterized the structure and function of a neuron-specific splice variant of the Bβ regulatory gene termed Bβ2. I found that the divergent N-terminus of Bβ2 does not...

Securing property plays a crucial role in human life. Therefore, an adaptive multilevel wireless security system (ML-WSS) based on the internet of things (IoT) has been proposed to observe and secure certain place. ML-WSS consists hardware software components, such as set sensors, Wi-Fi module, operation monitoring mobile application (OMM). The OMM is designed remotely monitor control through I...

In this paper we address the research question, how an structuring model for digital object memories (DOMe) has to be designed. Primary goal is to identify and develop components and processes of an architecture concept particularly suited to represent, manage, and use digital object memories. In order to leverage acceptance and deployment of this novel technology, the envisioned infrastructure...

oral malignant melanoma (omm) accounts for 5% of all oral malignancies. it is a rare aggressive neoplasm usually found on the hard palate and gingiva. the etiology is unknown, but tobacco and chronic irritation are suggested as probable causative factors. over 30% of the cases have been reported to arise from pre-existing pigmented lesions. a biopsy is required to establish the diagnosis and th...