نتایج جستجو برای: oligonucleotides
تعداد نتایج: 12178 فیلتر نتایج به سال:
MicroRNAs are small non-coding RNA molecules involved in the epigenetic regulation of carcinogenesis. miR-204-5p was shown to be among most downregulated miRs melanoma versus benign melanocytic lesions. SIRT1 as a gene target regulates proliferation, apoptosis, migration cancer cells whereas BCL2 is well known by it’s antiapoptotic functions. Therefore B16-bearing mice were treated synthetic mi...
Here we used solid-phase methods to prepare oligonucleotides carrying fibrin/ filaggrin citrullinated peptides. Post-synthetic conjugation protocols were successfully applied for the synthesis of oligonucleotides carrying small peptides. A stepwise protocol using acid treatment for the final deprotection allowed the preparation of polypyrimidine oligonucleotides carrying longer and arginine-ric...
Many important molecular applications, such as DNA oligonucleotide arrays, utilize synthetic oligonucleotides attached to solid supports. The most accessible approach for producing an oligonucleotide microarray is to synthesize individual oligonucleotides and subsequently immobilize them to a solid surface. For this immobilization to take place, the oligonucleotides must be modified with a func...
A research program has applied the tools of synthetic organic chemistry to systematically modify the structure of DNA and RNA oligonucleotides to learn more about the chemical principles underlying their ability to store and transmit genetic information. Oligonucleotides (as opposed to nucleosides) have long been overlooked by synthetic organic chemists as targets for structural modification. S...
Software has been developed to assist RNA fingerprinting analysis. One program generates, from a DNA sequence data file, the oligonucleotides resulting from digestion of an RNA transcript labeled with any specified nucleotide(s). Oligonucleotides are sorted according to their position on the fingerprint. Expected molar yields and products of secondary redigestion are also indicated. A second pr...
A carboxy derivative of the antimalarial cytotoxic drug cryptolepine was introduced into synthetic oligonucleotides by reaction of the carboxy derivative of cryptolepine with oligonucleotides carrying an amino group either at the 3'- or at the 5'-end. Oligonucleotides carrying the cryptolepine derivative bind their complementary sequences with greater affinity than unmodified ones. When cryptol...
The European Medicines Agency, the U.S. Food and Drug Administration, other regulatory agencies expect that all pharmaceutical products be assessed for potential presence of N-nitrosoamine (nitrosamine) impurities. This white paper addresses general considerations nitrosamine risk assessments oligonucleotide products. authors propose a assessment platform which should facilitate safe, consisten...
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