BACKGROUND Mammalian fossils from the Eppelsheim Formation (Dinotheriensande) have been a benchmark for Neogene vertebrate palaeontology since 200 years. Worldwide famous sites like Eppelsheim serve as key localities for biochronologic, palaeobiologic, environmental, and mammal community studies. So far the formation is considered to be of early Late Miocene age (~9.5 Ma, Vallesian), representi...

the ali-abad porphyry copper deposit is located in the central iranian magmatic belt. as a result of subduction magmatism, oligo-miocene leucogranitoid rocks have intruded into conglomerates of lower cretaceous age. due to contact metamorphism the following mineral assemblage has occurred in the altered conglomerate: garnet (andradite-grossular) + epidote+ quartz + calcite + pyrite skarnificati...

The Darıderesi mineralisation was recently discovered in the Balya district which hosts Pb-Zn (Ag) deposits including Arı Mağara-Balya Main and Hastanetepe-Balya North. is a structurally controlled hydrothermal associated replacement hosted shale-mudstone carbonaceous horizons within Karakaya Complex. formed three main stages as pre-ore calc-silicate alteration, ore, supergene alteration. subst...

study area is located in district of bajestan and ferdows cities, ne of iran. structurally, this area is part of lut block. the oldest exposed rocks, to the north of intrusive rocks and in eastern bajestan, are meta-chert, slate, quartzite, thin-bedded crystalline limestone and meta-argillite. the sedimentary units are: sardar formation (carboniferous), jamal formation (permian), sorkh shale an...

principal skarn deposits along the northern margin of the ahar batholith from west to east include mazraeh, vine and gowdoul skarn deposits. among these skarn deposits, the mazraeh cu-fe skarn deposit is the most typical skarn deposit in the nw iran. this skarn deposit is located 5 km. north of mazraeh village and 20 km north of ahar town. the origin and development of the skarn can be related ...

Recent onshore New Jersey drilling (Ocean Drilling Program Leg 150X) provided excellent recovery of lower to middle Miocene sequences that we dated with Sr isotopic stratigraphy. Sequence boundaries correlate with deep-sea dO increases (inferred glacioeustatic lowerings), indicating a primary control by global sea-level change. Maryland Miocene outcrops appear to correlate with New Jersey seque...

Deep-time perspectives in macroecology are essential with regard to understanding the impact of climate forcing on faunal communities. Using late Miocene rodent faunas (12 to 5 Ma) from two different biogeographical provinces from southwestern Europe, we asked whether the waxing and waning of faunas with dissimilar ecological affinities tracked climate in different ways. The latest middle Mioce...

Oligonucleotides homologous to 3'-telomere overhang (T-oligos) trigger inherent telomere-based DNA damage responses mediated by p53 and/or ATM and induce senescence or apoptosis in various cancerous cells. However, T-oligo has limited stability in vivo due to serum and intracellular nucleases. To develop T-oligo as an innovative, effective therapeutic drug and to understand its mechanism of act...

T-oligo, an 11-base oligonucleotide homologous to the 3'-telomeric overhang, is a novel, potent therapeutic modality in melanoma and multiple other tumor types. T-oligo is proposed to function in a manner similar to experimental disruption of the telomere overhang and induces DNA damage responses including apoptosis, differentiation and senescence. However, important components involved in T-ol...