نتایج جستجو برای: odorant

تعداد نتایج: 3893  

Journal: :PLoS ONE 2009
Nathalie Mandairon Johan Poncelet Moustafa Bensafi Anne Didier

In humans, the pleasantness of odors is a major contributor to social relationships and food intake. Smells evoke attraction and repulsion responses, reflecting the hedonic value of the odorant. While olfactory preferences are known to be strongly modulated by experience and learning, it has been recently suggested that, in humans, the pleasantness of odors may be partly explained by the physic...

Journal: :Brain research 2006
Sebastian Brauchi Christian Cea Jorge G Farias Juan Bacigalupo Juan G Reyes

Multicellular organisms undergo programmed cell death (PCD) as a mechanism for tissue remodeling during development and tissue renewal throughout adult life. Overdose of some neuronal receptor agonists like glutamate can trigger a PCD process termed excitotoxicity in neurons of the central nervous system. Calcium has an important role in PCD processes, especially in excitotoxicity. Since the no...

Journal: :Journal of neurophysiology 2013
Timothy Connelly Agnes Savigner Minghong Ma

Sensory systems need to tease out stimulation-evoked activity against a noisy background. In the olfactory system, the odor response profile of an olfactory sensory neuron (OSN) is dependent on the type of odorant receptor it expresses. OSNs also exhibit spontaneous activity, which plays a role in establishing proper synaptic connections and may also increase the sensitivity of the cells. Howev...

Journal: :Chemical senses 2004
Noriyo Suzuki Masakazu Takahata Takayuki Shoji Yuko Suzuki

Electro-olfactogram (EOG) oscillations induced by odorant stimulation have been often reported in various vertebrates from fishes to mammals. However, the mechanism of generation of EOG oscillations remains unclear. In the present study, we first characterized the properties of EOG oscillations induced by amino acid odorants in the rainbow trout and then performed a computer simulation based on...

2015
Olivia Baud Shuguang Yuan Luc Veya Slawomir Filipek Horst Vogel Horst Pick

A multi-gene family of ~1000 G protein-coupled olfactory receptors (ORs) constitutes the molecular basis of mammalian olfaction. Due to the lack of structural data its remarkable capacity to detect and discriminate thousands of odorants remains poorly understood on the structural level of the receptor. Using site-directed mutagenesis we transferred ligand specificity between two functionally re...

2018
Kate E. Yu Do-Hyoung Kim Yong-In Kim Walton D. Jones J. Eugene Lee

Animals use their odorant receptors to receive chemical information from the environment. Insect odorant receptors differ from the G protein-coupled odorant receptors in vertebrates and nematodes, and very little is known about their protein-protein interactions. Here, we introduce a mass spectrometric platform designed for the large-scale analysis of insect odorant receptor protein-protein int...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2006
Hartwig Spors Matt Wachowiak Lawrence B Cohen Rainer W Friedrich

Odorants are first represented in the brain by distributed patterns of activity in the olfactory bulb (OB). Although neurons downstream of sensory inputs respond to odorants with temporally structured activity, sensory inputs to glomeruli are typically described as static maps. Here, we imaged the temporal dynamics of receptor neuron input to the OB with a calcium-sensitive dye in the olfactory...

Journal: :Biochemical Society transactions 2003
K Mori

The olfactory system is unique in that the sensory input is in the form of molecular information carried in a vast variety of odorants. Nearly 1000 types of odorant receptors mediate the initial detection and discrimination of odorants at the molecular-feature level. The discrimination at the molecular level is converted into that at the cellular level (olfactory sensory neurons) by the one sen...

Journal: :Chemical senses 2006
Caren M Armstrong Loren M DeVito Thomas A Cleland

Behavior genetics studies in mice demand efficient training protocols for rapid phenotypic screening. However, the capacity of neonatal mice to form and retain associative memories has been difficult to study due to their limited sensorimotor capacities. The present study describes a method for robust, naturalistic associative learning in neonatal mice as young as 3 days old. After removal of t...

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