Introduction Odontoblasts and ameloblasts are columnar cells that characterize by a highly polarized distribution of organelles. Junctional complexes and the cytoskeleton are important in maintaining ameloblast and odontoblast cell polarity and cell-cell interactions. In addition, cell adhesion is a key regulator of gene expression and cell differentiation. Tight junction binding proteins prote...

Nuclear factor I-C (NFI-C) plays a pivotal role in various cellular processes such as odontoblast and osteoblast differentiation. Nfic-deficient mice showed abnormal tooth and bone formation. The transplantation of Nfic-expressing mouse bone marrow stromal cells rescued the impaired bone formation in Nfic-/- mice. Studies suggest that NFI-C regulate osteogenesis and dentinogenesis in concert wi...