A plethora of medical consequences have been associated with the syndrome of obstructive sleep apnoea (OSA). These are global, affecting nearly every body function, and have been related to two key pathophysiological findings in sleep apnoea: repetitive falls in oxyhaemoglobin saturation during sleep, and recurrent arousals from sleep which terminate apnoea episodes. Sufferers of OSA may experi...

Baroreflex control of heart rate during sleep (baroreflex sensitivity; BRS) has been shown to be depressed in obstructive sleep apnoea (OSA), and improved after treatment with continuous positive airway pressure (CPAP). Whether CPAP also acutely affects BRS during sleep in uncomplicated severe OSA is still debatable. Blood pressure was monitored during nocturnal polysomnography in 18 patients a...

The aim of the present study was to estimate slow-wave activity (SWA), a marker of sleep homeostasis, in children with obstructive sleep apnoea (OSA) before and after adenotonsillectomy (AT) compared with untreated OSA children (comparison group). 14 children with OSA (mean ± sd age 6.4 ± 2.5 yrs; apnoea-hypopnoea index (AHI) 10.0 ± 10.3 events·h⁻¹) who underwent AT were consecutively recruited...

Obstructive sleep apnoea (OSA) is a common disease which characterised by repetitive collapse of the upper airways during resulting in chronic intermittent hypoxaemia and frequent microarousals, consequently leading to sympathetic overflow, enhanced oxidative stress, systemic inflammation, metabolic disturbances. OSA associated with increased risk for cardiovascular morbidity mortality, acceler...

Obstructive sleep apnoea (OSA) has become a major public health concern as its incidence and severity have increased in tandem with the obesity epidemic. In children, OSA is now recognized as a common disorder and can be associated with significant morbidity. OSA belongs to a spectrum of diagnoses known as sleep-related breathing disorders in which the airway is completely (apnoea) or partially...

*Additional Professor, **Professor and Head, Department of Pulmonary Medicine, T. N. Medical College, B.Y.L. Nair Hospital, Mumbai, 400008 Received: 27.01.2012; Revised: 28.05.2012; Accepted: 25.05.2012 A 36 years old lady, presented with history of loud snoring, excessive daytime sleepiness (EDS), nocturnal choking, nocturia, non refreshing sleep and memory lapses for last 7 years. Along with ...

Obstructive sleep apnoea (OSA) carries an increased risk of ischaemic stroke, but the underlying mechanism is not clear. As right-to-left shunting can occur through a patent foramen ovale (PFO) during periods of apnoea, we investigated nocturnal changes in fibrinolytic activity and platelet function in subjects who had OSA with or without PFO and in controls. We determined plasminogen activator...

Abstract Background Obstructive Sleep Apnoea (OSA) in pregnancy is associated with increased maternal and neonatal morbidity. Evidence supporting use of traditional screening tools (e.g. Epworth Sleepiness Scale STOP-BANG) inconsistent, especially for people class III obesity. This study aims to determine factors referral sleep clinic diagnosis OSA pregnant Method Retrospective audit records ob...

In patients with obstructive sleep apnoea (OSA), the very low frequency power spectral density index (VLFI) derived from analysis of heart rate correlates with the severity of obstructive apnoeas. VLFI is also associated with Cheyne-Stokes respiration/central sleep apnoea (CSR/CSA) in congestive heart failure (CHF). The present authors have tested the hypothesis that per cent VLFI, derived from...

Objectives: Obstructive sleep apnoea (OSA) is a condition wherein collapse of the upper airway during results in decreased or complete cessation airflow. The association OSA with increased cardiovascular morbidity, mortality, and various risk factors known for long time. Metabolic syndrome cluster metabolic abnormalities, insulin resistance as central pathophysiological feature ‘Syndrome X’ Z’....