A tube type mini electrode has been made to detect paracetamol levels in herbal medicine, the is of a glass with diameter 0.7 cm, length 3 cm. As membrane mixture chitosan, activated carbon from rice husk, and cetyl trimethyl ammonium (CTA)-paracetamol. The internal solution standard 0.01 M phosphoric acid pH 2. average sensitivity sensor (22.60 ± 0.01) mV/decade linear concentration range 10-6...

Protein methylation is a common posttranslational modification that mostly occurs on arginine and lysine residues. Arginine methylation has been reported to regulate RNA processing, gene transcription, DNA damage repair, protein translocation, and signal transduction. Lysine methylation is best known to regulate histone function and is involved in epigenetic regulation of gene transcription. To...

To elucidate the in vivo pharmacological activities of magnesium lithospermate B (MLB), an active constituent of Radix Salviae Miltiorrhizae, in the rat, its metabolic fate both in vivo and in vitro was investigated. High-performance liquid chromatography revealed that four major metabolites with lower polarity were excreted into bile after intravenous and oral administration of MLB. The metabo...

both as crystals and in solution.1–3 A cyclic structure containing N-methylamide can be easily constructed, since the cis preference arranges two moieties attached to the N-methylated amide close to each other. In this paper, we report on the crystal structure of 2,8,14-trimethyl-2,8,14-triazatetracyclo[142,24,7,210,13]tetracosa-4,6,10,12,16,18,19,21,23-nonaene3,9,15-trione (1, Fig. 1), which w...

PURPOSE Cholesterol is a major lipid constituent of biological membranes which could be included in cyclodextrin (CD) cavities. Solubilization and cell extraction of cholesterol have been previously performed in order to study its interaction with beta-CD and methylated beta-derivatives notably. The present work aims at confirming the formation of inclusion complexes between these CDs and chole...

Carnitine (3-hydroxy-4-trimethylammonio-butanoate), an essential cofactor for mitochondrial long-chain fatty acid oxidation, is synthesized in mammals, and consequently is present in diets containing meat products. When the diet does not contain carnitine rats and man appear to produce sufficient carnitine to maintain homoeostatis. Carnitine is the product of the essential amino acids lysine an...

Tacrolimus (TAC) suspension is used to treat moderate severe atopic keratoconjunctivitis (AKC) and vernal (VKC). The objectives of this study were formulate the hydrophobic compound TAC in an aqueous eye drop formulation its ocular biodistribution on topical application a healthy rabbit model, with overall aim using AKC VKC. A thin-film hydration method was encapsulate within chitosan-based amp...

Designing scaffolds made from natural polymers may be highly attractive for tissue engineering strategies. We sought to produce and characterize chitosan-coated collagen membranes and to assess their efficacy in promoting chondrocyte adhesion, growth, and cytokine secretion. Porous collagen membranes were placed in chitosan solutions then crosslinked with glutaraldehyde vapor. Fourier transform...

The potent antioxidant properties of rosemary (Rosmarinus officinalis) extracts have been attributed to its major diterpene, carnosic acid. Carnosic acid has received considerable attention in food science and biomedicine, but little is known about its function in the plant in vivo. We recently found that highly oxidized diterpenes increase in rosemary plants exposed to drought and high light s...

N-sodium acrylate-O-carboxymethyl chitosan [CMCH-g-PAA(Na)] bound Fe3O4 nanoparticles were developed as a novel magnetic nanoparticles with an ionic structure that can be potentially used in many fields. CMCH-g-PAA (Na) was obtained by grafting of sodium polyacrylate on O-carboxymethyl chitosan, which is an amphiphilic polyelectrolyte with the biocompatibility and biodegra...