CMAJ • SEPTEMBER 7, 2010 • 182(12) © 2010 Canadian Medical Association or its licensors 1315 The 2002 guidelines for the management of osteoporosis published by Osteoporosis Canada identified adequate vitamin D status, in addition to calcium from diet or supplements, as essential for the prevention of osteoporosis. Since then, our knowledge of the role of vitamin D (both D2 and D3) in fractures...

BACKGROUND Lepidium meyenii Walpers (maca) is an herb known as a traditional nutritional supplement and widely used in Peru, North America, and Europe to enhance human fertility and treat osteoporosis. The secondary metabolites of maca, namely, maca alkaloids, macaenes, and macamides, are bioactive compounds, but their targets are undefined. METHODS The pharmacophore-based PharmaDB targets da...

Osteoporosis and low bone mineral density affect millions of Americans. The majority of adults in North America have insufficient intake of vitamin D and calcium along with inadequate exercise. Physicians are aware that vitamin D, calcium and exercise are essential for maintenance of bone health. Physicians are less likely to be aware that dietary insufficiencies of magnesium, silicon, Vitamin ...

Osteoporosis (OMIM166710) is a common skeletal disorder characterized by low bone mass and microarchitectural deterioration of bone tissue with increased susceptibility to fracture. Osteoporosis has a complex etiology and is considered a multifactorial polygenic disease in which genetic determinants are modulated by hormonal, environmental, and nutritional factors. Estrogens are known to play a...

Introduction : Reduced bone mass density (BMD) is frequent in patients with cystic fibrosis (CF). Pathogenesis of CF bone disease is multifactorial. Many studies suggest that there is genetic component, independent of the disease severity and nutritional deficits. Aim: To determine the prevalence and identify determinants of reduced BMD in CF patients. Material and methods: The study included 8...

Osteoporosis is a global health problem characterized by low bone mass and an increase in bone fragility. It is now well accepted that dietary factors play a central role in bone development and health. Diet that lacks adequate minerals is considered to be a risk factor for osteoporosis. The food supplement, Aquamin, is a natural, multi-mineral derived from the red algae Lithothamnion corallioi...

Iron is essential in oxygen transport and participates in many enzymatic systems in the body, with important roles in collagen synthesis and vitamin D metabolism. The relationship between iron and bone health comes from clinical observations in iron overload patients who suffered bone loss. The opposite scenario--whether iron deficiency, with or without anemia, affects bone metabolism--has not ...

The determination of chemical imbalances typically present at the onset of some aggressive diseases may be used for early diagnosis, which could reduce mortality and contribute for more efficient treatments. An interesting approach for nutritional and toxicological studies is the determination of minerals in fingernails and toenails. The concentrations of certain elements in these samples can b...