background: normal tissue toxicity continues to remain as a major challenge for radiation oncologists for delivering the total dose to the tumour cells in cancer patients. cellular, molecular and plasma based early biomarkers to predict the overreactions and non-overreactions of normal tissue toxicity before the initiation of radiotherapy can be valuable for personalised treatment. the aim of t...

coronary artery disease (cad) including myocardial infarction (mi) as its complication, is one of the most common heart diseases worldwide and also in iran, with extremely elevated mortality. cad is a multifactorial disorder. twin and family studies at different loci have demonstrated that genetic factors have an important role in the progression of cad. many studies have reported a significant...

background: bcl-2 is the most important anti-apoptotic regulator and bax is a pro-apoptotic protein. the status of these parameters or the ration of bcl-2 to bax is important in malignant cell fate as well as normal cells. methods: sixty-two all patients and 62 healthy sex-and age-matched controls were studied. after genotyping, the promoter region of the bax and bcl-2 genes by rflp-pcr method ...

background: single nucleotide polymorphism (snps) are considered as one of the underlying causes of male infertility. proper sperm chromatin packaging which involves replacement of histones with protamines has profound effect on male fertility. over 20 snps have been reported for the protamine 1 and 2. materials and methods: the aim of this study was to evaluate the frequency of two previously ...

Identification of polymorphism is the key for genetic mapping, diagnosis and marker-assisted selection. Restriction fragment-length polymorphisms (RFLPs) and short tandem repeats (STRs), also known as microsatellites, are commonly used genetic markers. Until discovery of STRs, RFLPs were used for genetic mapping, but bi-allelic polymorphism of RFLP limited its use as a marker. Although STRs are...

The diacylglycerol acyltransferase 1 gene (DGAT1) was identified as a strong candidate gene affecting mutton quality traits in sheep. Single nucleotide polymorphism creates a single base mutation (C to T) in AGCT site of endonuclease AluI. DGAT1 is one of the candidate genes to improve carcass characteristics in feedlot animals. In order to study area T487C in exon 17 of the DGAT1 polymorphism,...

Genetic Analysis Workshop 18 provided a platform for evaluating genomic prediction power based on single-nucleotide polymorphisms from single-nucleotide polymorphism array data and sequencing data. Also, Genetic Analysis Workshop 18 provided a diverse pedigree structure to be explored in prediction. In this study, we attempted to combine pedigree information with single-nucleotide polymorphism ...

BACKGROUND Atopic dermatitis is the most common chronic inflammatory skin disease. A complex interaction of both genetic and environmental factors is thought to contribute to the disease. AIMS To evaluate whether single nucleotide polymorphisms in the TLR2 gene c.2258C>T (R753Q) (rs5743708) and TLR2 c.-148+1614T>A (A-16934T) (rs4696480) (NM_0032643) are associated with atopic dermatitis in Tu...

Background and Aim: Breast cancer is the most common type leading cause of cancer-induced deaths in women, worldwide. The Fibroblast Growth Factor Receptor 2 (FGFR2) a tyrosine kinase receptor that plays an essential role growth, invasion, movement, angiogenesis tumor cells. Several single nucleotide polymorphisms have been found intron FGFR2 gene, i.e., associated with high risk breast cancer....