Background and Objective. Suppression of apoptosis has been proposed as a mechanism responsible for epidermal thickness in psoriasis. Survivin is a member of the inhibitor of apoptosis family. Nuclear factor kappa B (NF-κB) is one of the transcriptional factors that regulate many genes affecting apoptosis. The aim of this study was to determine survivin and NF-κB expressions in psoriasis in com...

Activation of nuclear factor kappa-B (NF-κB) results in its translocation from the cytoplasm to the nucleus and binding to the promoters of a large number of genes, including those encoding proinflammatory cytokines and other mediators that can contribute to organ system dysfunction in severe infection. While inhibition of NF-κB activation has been proposed as a therapeutic approach in critical...

This paper reports a simple, rapid molecular binding scheme for the detection and quantification of the transcription factor nuclear factor kappa B and other DNA binding proteins without any separation or immobilization step.

Submit Manuscript | http://medcraveonline.com Abbreviations: NF-κB: Nuclear Factor Kappa-Light-ChainEnhancer of Activated B Cells; NO: Nitric Qxide; TNF-α: Tumor Necrosis Factor α; IL-1β: Interleukin-1β; RA: Rheumatoid Arthritis; IBD: Inflammatory Bowel Disease; COPD: Chronic Obstructive Pulmonary Disease; IKK-1: Inhibitor of Kappa B Kinase; ROS: Reactive Oxygen Species; INOS: Inducible Nitric ...