نتایج جستجو برای: npc1l1
تعداد نتایج: 237 فیلتر نتایج به سال:
Non-alcoholic fatty liver disease (NAFLD) is associated with the metabolic syndrome characterized by dislipidemia and insulin resistance. We hypothesized that ezetimibe, an inhibitor of NPC1L1, improves these metabolic disorders in Zucker obese fatty rats (ZOF). Ezetimibe significantly lowered total cholesterol and triglycerides in ZOF with prominent reduction in the remnant lipoprotein fractio...
For research and clinical application, the central role of oxidative signalling in cardiovascular pathophysiology –6 positions measures of the redox state conceptually as ideal biomarkers. Despite this overwhelming biological plausibility, no redox biomarker is currently in clinical use, nor have antioxidants provided any clinical benefit in large trials. Recent insights into the mechanistic co...
Cholesterol homeostasis is required to maintain normal cellular function and avoid the deleterious effects of hypercholesterolemia. Here we show that the Drosophila DHR96 nuclear receptor binds cholesterol and is required for the coordinate transcriptional response of genes that are regulated by cholesterol and involved in cholesterol uptake, trafficking, and storage. DHR96 mutants die when gro...
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