An L-glutamic acid based bolaamphiphile was observed to self-assemble into a novel "helical spherical-nanotube" with a molecular monolayered structure within a tubular wall.

Activation of β-catenin, the principal mediator of canonical Wnt signaling, is a common pathologic finding in a wide variety of chronic kidney diseases (CKD). While β-catenin is induced predominantly in renal tubular epithelium in CKD, surprisingly, depletion of tubular β-catenin had little effect on the severity of renal fibrosis. Interestingly, less apoptosis was detected in interstitial fibr...

Presented topic is from the research fields called Artificial Life and Artificial Intelligence (AI). In this paper, there is presented novel approach to designing agent architectures with its requirements. The approach is inspired by inherited modularity of biological brains and agent architectures are represented here as set of given reusable modules connected into a particular topology. This ...

background & objectives: tubular adenomas are rare benign epithelial tumours of breast affecting predominantly females of child bearing age group. till now, very small number of cases have been reported in the literature. present study was carried out to evaluate the clinico-pathological features of tubular adenoma cases diagnosed during three years study period along with discussion of pos...

BACKGROUND Ninety percent of glucose filtered by the glomerulus is reabsorbed by a sodium-glucose cotransporter 2 (SGLT2), which is expressed mainly on the apical membrane of renal proximal tubules. Since SGLT-2-mediated glucose reabsorption is enhanced under diabetic conditions, selective inhibition of SGLT2 has been proposed as a potential therapeutic target for the treatment of patients with...

Na⁺/H⁺ exchange activity in the apical membrane of the proximal tubule is fundamental to the reabsorption of Na⁺ and water from the filtrate. The role of this exchange process in bicarbonate reclamation and, consequently, the maintenance of acid-base homeostasis has been appreciated for at least half a century and remains a pillar of renal tubular physiology. More recently, apical Na⁺/H⁺ exchan...

Albuminuria promotes tubular injury and cell death, and is associated with faster progression of chronic kidney disease (CKD) to end-stage renal disease. However, the molecular mechanisms regulating tubular cell death in response to albuminuria are not fully understood. Brain abundant signal protein 1 (BASP1) was recently shown to mediate glucose-induced apoptosis in tubular cells. We have stud...

This study was undertaken to define whether differences in the expression of Wnt pathway components are present between normal colonic mucosa, early (tubular) adenomas and villous adenomas which have a higher malignant potential. Normal mucosa, tubular adenomas and villous adenomas were obtained from twelve patients. RNA was isolated and utilized for Wnt pathway-specific membrane array expressi...

In this paper we introduce temporal action graph games (TAGGs), a novel graphical representation of imperfect-information extensive form games. We show that when a game involves anonymity or context-specific utility independencies, its encoding as a TAGG can be much more compact than its direct encoding as a multiagent influence diagram (MAID). We also show that TAGGs can be understood as indir...

This paper investigates the basic problem of computing crossing-free straight-line 3D grid drawings of graphs such that the overall volume is small. Motivated by their relevance in the literature, we focus on families of graphs having constant queue number and on k-trees. We present algorithms that compute drawings of these families of graphs on 3D grids consisting of a constant number of paral...