نتایج جستجو برای: novel anticancer agent

تعداد نتایج: 1047481  

2017
Li Ding Ruonan Sun Xinyue Zhang

Rap2b is a novel p53 target we have identified recently. Knockdown of Rap2b sensitizes HCT116 cells to adriamycin-induced apoptosis, indicating that Rap2b promotes adriamycin resistance in cancer cells. In the present study, we designed a nanostructure-based drug/gene delivery system to evaluate the potential of Rap2b siRNA as a therapeutic agent against human cancers. Specifically, after co-in...

Journal: :Molecular pharmacology 2007
Jiri Neuzil Marco Tomasetti Yan Zhao Lan-Feng Dong Marc Birringer Xiu-Fang Wang Pauline Low Kun Wu Brian A Salvatore Steven J Ralph

The search for a selective and efficient anticancer agent for treating all neoplastic disease has yet to deliver a universally suitable compound(s). The majority of established anticancer drugs either are nonselective or lose their efficacy because of the constant mutational changes of malignant cells. Until recently, a largely neglected target for potential anticancer agents was the mitochondr...

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