Seven human-specific Alu markers were studied in 574 unrelated individuals from 10 endogamous groups and 2 hill tribes of Tamil Nadu and Kerala states. DNA was isolated, amplified by PCR-SSP, and subjected to agarose gel electrophoresis, and genotypes were assigned for various Alu loci. Average heterozygosity among caste populations was in the range of 0.292-0.468. Among tribes, the average het...

Type 1 diabetes (T1D) is a polygenic autoimmune disease. Susceptibility to T1D is strongly linked to a major genetic locus that is the major histocompatibility complex (MHC) and several other minor loci including insulin, CTLA4 that contribute to diabetes risk in an epistatic way. MHC harbours genes whose primary function is to govern immune responsiveness. Being the most polymorphic genomic re...

PRIMARY AIM To establish the cephalometric standards for hard and soft tissues of the facial skeleton for north Indian population. METHODS The sample comprised of lateral cephalograms taken in natural head position of 100 participants (50 men, 50 women). The cephalograms were traced, analyzed and interpreted using the landmarks and values given by Burstone's analysis for hard tissue and Legan...

It has been evident that Glutathione S-transferase (GST) gene deficiency may contribute to the development of asthma. Therefore, we aimed to assess the association of GSTT1 and GSTM1 deficiency with passive maternal smoking (MS) during pregnancy with asthma in north Indian children. It was a hospital based case-control study, 175 bronchial asthma cases and 175 controls, aged 1 year -15 years we...

The present study was designed to investigate the association between circulating Orexin-A level with metabolic risk factors in North Indian adult women. 342 women were enrolled for the case-control study, 172 women were with metabolic syndrome (mets) and 170 healthy control women were without metabolic syndrome, (womets) according to (NCEP ATP III criteria). Circulating Orexin-A level was dete...

A prospective study was carried out to establish normative data for splenic dimensions in North Indian population and their correlation with physical standard on abdominal CT of 21 patients aged between 20 and 70 years having no splenic disorders. Splenic volume was measured by two methods-volume and surface rendering technique of Able 3D doctor software and prolate ellipsoid formula. Volumes m...

Background Obesity is a very common disorder resulting from an imbalance between food intake and energy expenditure, and it has a substantial impact on the development of chronic diseases. The aim of this study was to examine the association of INSIG2 (rs7566605) gene polymorphism with obesity and obesity associated phenotypes in North Indian subjects. Methods The variants were investigated ...

AIM This study was conducted to determine whether the standards of dental maturation given by Demirjian et al. are applicable to North Indian children and to assess the relationship between dental age and chronological age. METHODS In this study OPGs of 100 females of 8-14 years were taken, and dental age was calculated according to the Demirjian method. Chronological age was recorded and c...

In this preliminary study, we measured event-related potentials (ERPs) to melodic expectancy violations in a cross-cultural context. Subjects (n= 10) were college-age students born and raised in the United States. Subjects heard 30 short melodies based in the Western folk tradition and 30 from North Indian classical music. Each melody was presented in its original and deviation form, and subjec...

OBJECTIVES We examined the prevalence and clinical correlates of pathological gambling among 1228 American Indian and Hispanic American veterans in the southwest and north central regions of the United States. METHODS We surveyed a community sample of American Indian and Hispanic American veterans to obtain data on psychiatric disorder and treatment. RESULTS American Indian veterans had a 1...