In this essay we present two themes. The first is a factual review of the behavioral and neurological differences in language and cognition between people with and without familial left handedness: These differences begin to justify the claim that there is a continuum of how language and cognition are represented in the brain, reflecting a quantitative difference in the role of the right hemisp...

Cells exhibit a high degree of variation in levels of gene expression, even within otherwise homogeneous populations. The standard model to describe this variation centers on a gamma distribution driven by stochastic bursts of translation. Stochastic bursting, however, cannot account for the well-established behavior of strong transcriptional repressors. Instead, it can be shown the very comple...

introduction and aims: do h. pylori isolates from normal and dyspeptic patients have similar genetic profiles? since genotype variation occurs within h. pylori population with high frequency, it is tempting to exploit techniques such as rapd-pcr to examine the possible correlation between specific h. pylori genotypes and different peptic diseases. in this study, h. pylori isolates from differen...

We develop a model of continuous spherical shapes and use it to analyze the anatomy of the hippocampus. To account for the geometry of bends and folds, the model relies on a geodesic metric that is sensitive to first-order deformations. We construct an atlas of the hippocampus as a mean shape and develop statistical models to characterize quantitative and qualitative normal shape variation. We ...

The aims of this study were to classify normal occlusion samples into specific skeletal types and to analyze the dentoalveolar compensation in a normal occlusion in order to provide the clinically applicable differential diagnostic criteria for an individual malocclusion patient. Lateral cephalograms of 294 normal occlusion samples, who were selected from 15,836 adults through a community denta...

Genetics of the variability of normal and diseased brain structure largely remains to be elucidated. Expansions of certain trinucleotide repeats cause neurodegenerative disorders of which Huntington's disease constitutes the most common example. Here, we test the hypothesis that variation within the IT15 gene on chromosome 4, whose expansion causes Huntington's disease, influences normal human ...

There is growing evidence that gene expression profiling of peripheral blood cells is a valuable tool for assessing gene signatures related to exposure, drug-response, or disease. However, the true promise of this approach can not be estimated until the scientific community has robust baseline data describing variation in gene expression patterns in normal individuals. Using a large representat...

Glottalized voice quality has been observed consistently in normal utterances in a variety of locations, including as an allophone of voiceless stops (in e.g., Hat,eld, butler), in word-initial vowels at intonation phrase onsets and at pitch accents, and at the ends of utterances. In this study of American English, we examine glottalizations at phrase boundaries which are medial or "nal in an u...

We used Wick’s normal-ordering technique, squeezed creation and annihilation operators, and a variation method, to find the eigenvalues of the general pure ?x2m potential. Numerical results for low-lying energy levels of pure quadratic, quartic, sextic, octic and decatic potentials, for different values of ? were obtained. Some interesting features of these energy levels are explained.