The identification of new biomarkers for preneoplastic pancreatic lesions (PanINs, IPMNs) and early pancreatic ductal adenocarcinoma (PDAC) is crucial due to the diseases high mortality rate upon late detection. To address this task we used the novel technique of matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS) on genetically engineered mouse models (GEM) of p...

STATEMENT OF THE PROBLEM Soft tissue reactive lesions are the most common lesions of the oral cavity. Although many studies have shown the interaction of mast cells with fibroblasts and their participation in fibrosis, the role of mast cells in these lesions is not well understood. PURPOSE The aim of this study was to evaluate the mast cells (MCs) count in oral soft-tissue reactive lesions in...

introduction: few studies on benign soft tissue tumors of oral cavity have been conducted in an iranian population. the purpose of this study was to evaluate the prevalence of the benign soft tissue tumors of the oral cavity in three central pathology centers of rasht, iran. materials and methods: in this retrospective study, all benign soft tissue tumors of the oral cavity, were retrieved from...

the aim of the present study was to determine the relationship between histopathological lesions and tissue enzymes in chickens affected by marek's disease.five apparently healthy chickens(as control group)and 25 chickens affected by marek's disease were selected. after consideration of history and gross lesions, tissue samples were collected from kidney, liver, heart, ovary, pectoral...

fibro-osseous lesions of the maxillofacial region are a distinct group of pathological condition in which all variations demonstrate replacement of normal bone by a fibrous connective-tissue matrix within which varying amounts or combinations of osteoid & mature bone and, in some instances, cementing like tissue are deposited. All of them have similar clinical, radiologic and histologic feature...

Hamartomas are tumor-like masses comprising disorganized normal tissue elements. To date, spontaneous hamartomas have been reported in several organs and tissues rodents but not the lungs. Here, we report first case of a hamartoma lungs 108-week-old female Wistar Hannover rat. Grossly, white spot, 7 mm diameter, was observed on costal surface left lung. Histopathologically, nodular lesions adja...

Introduction: A potentially malignant oral lesion (PMOL) refers to a morphologically altered tissue that has higher likelihood of developing cancer compared its apparently normal counterpart. Among PMOLs, leukoplakia is the most common found in mucosa. The aim study evaluate clinical characteristics lesions by comparing with histopathological diagnosis. Method: included descriptive analysis dat...

A 21 years old woman presented with a history of SLE and skin lesions on the arms, trunk, and abdomen. The left gluteal region was ulcerated and painful and occasionally extruded a chalky white material. The patient referred from rheumatology department for osteomyelitis assessment. On physical examination the patient had hard, nontender lesions on the proximal arms, lower abdomen and low...

OBJECTIVE The purpose of this retrospective study is to evaluate the diagnostic value of contrast enhanced sonography plus gastric distention sonography, the Double Contrast-enhanced Ultrasound (DCUS) in gastric lesions. METHODS 107 cases with pathology confirmed gastric lesions were retrospectively reviewed, DCUS and oral contrast agent ultrasound (US) were performed in all cases prior to op...

BACKGROUND Multiple sclerosis is an inflammatory demyelinating disease of the central nervous system and is the most common cause of neurologic disability in young adults. Despite antiinflammatory or immunosuppressive therapy, most patients have progressive neurologic deterioration that may reflect axonal loss. We conducted pathological studies of brain tissues to define the changes in axons in...