Gastric epithelial cells were incubated with a panel of clinical isolates of Helicobacter pylori, including nonulcer dyspepsia with gastritis (HS, n = 20), gastric ulcer (HU, n = 20), duodenal ulcer (HD, n = 21), and gastric cancer (HC, n = 20). HC strains induced a higher cyclooxygenase-2 (COX-2) expression than those from HS, HD, and HU. The bacterial virulence factors and the host cellular p...

P. Conz, Department of Nephrology, S. Bortolo Hospital, I-Vicenza (Italy) Dear Sir, Following the detection of Campylobacter pylori (CP) in the gastric mucosa of patients with gastric ulceration and its recognition as an etiologic agent of gastric pathology [1], several reports highlight the microorganism’s sensitivity to antimicrobial agents [2, 3]. Colloidal bismuth subcitrate was demonstrate...

OBJECTIVES No data are currently available on the prevalence and characteristics of functional dyspepsia among cement workers. Given the potential impact of dyspepsia on work performance, whether its prevalence is increased among workers exposed to cement dust was evaluated. METHODS Altogether 420 cement workers were enrolled in the study. According to the individual exposure levels to cement...

et al. Helicobacter pylori ''test and treat'' or endoscopy for managing dyspepsia: an individual patient data meta-analysis. Q In patients with dyspepsia, how cost effective is initial management with prompt endoscopy compared with a test and treat approach for inducing resolution of symptoms? METHODS Data sources: a randomised controlled trial (RCT) register established by the Dyspepsia Trials...

OBJECTIVES Dyspepsia is defined as persistent or recurrent abdominal pain or discomfort centered in the upper abdomen. Dyspepsia represents up to 8.3% of all primary care physician visits and causes huge economic costs to patients and to the economy as a whole. The aim of this study was to measure the influence of dyspepsia on work productivity of people within the Brazilian workforce. METHOD...

Dyspepsia is perhaps the most common gastrointestinal disease universally. The prevalence of dyspepsia ranges from 7-40% in population based studies worldwide. These figures vary with definition of dyspepsia used and also with the survey methodology. As with Western studies, functional dyspepsia (FD) predominates in Asia. With a decline in peptic ulcer disease and gastric cancer, the proportion...

Advances in basic and clinical research have revealed that Helicobacter pylori (H. pylori) infection plays an important role in the development of gastroduodenal dysmotility and hypersensitivity, as also in dyspepsia symptoms. In addition, recent studies have proposed an inflammation-immunological model for the pathogenesis of functional dyspepsia. Since H. pylori is the major microbe that prov...

A review of the recent literature indicates that even though dyspepsia is common in adults, only limited data regarding dyspepsia in children is available. Spiroglou et al, in a recent study, found over 50% of their patients, to have functional dyspepsia with the more commonly encountered symptoms being nausea, vomiting, early satiety, awaking from sleep and increased belching. Hyams et al, in ...

Dyspepsia is a syndrome characterized by symptoms and signs of upper gastrointestinal tract and the adjacent organs. It is estimated that 25% of the community have symptoms of dyspepsia syndrome. One-third of patients who visit general physician practices are patients with dyspepsia syndrome; and half of patients who visit gastroenterologists are also patients with dyspepsia syndrome. Dyspepsia...