Current non-invasive approaches for detection of urothelial cancers are suboptimal. We developed a test to detect urothelial neoplasms using DNA recovered from cells shed into urine. UroSEEK incorporates massive parallel sequencing assays for mutations in 11 genes and copy number changes on 39 chromosome arms. In 570 patients at risk for bladder cancer (BC), UroSEEK was positive in 83% of those...

Introduction: Thyroid nodules are frequent occurrences, and whenever diagnosed, it is necessary to rule out of malignancy. Valuable diagnostic methods in this field are sonography and fine needle aspiration. In this study while investigating these two methods, we compared them with postsurgical pathologic findings. Materials and methods: This is a cross sectional, descriptive-analytical study. ...

PURPOSE We evaluated the usefulness of the nuclear matrix protein 22 BladderChek (NMP22BC) test for the screening and follow-up of bladder cancer. MATERIALS AND METHODS From February 2006 to September 2009, we enrolled 1,070 patients who had hematuria or who were being followed up for bladder cancer. We compared the sensitivity and specificity of the NMP22BC test with those of urine cytology....

OBJECTIVE To evaluate sensitivity of effusion cytology in detecting malignancy. MATERIALS AND METHODS Effusion cytology was studied from 37 malignancy associated and 28 non malignancy associated ascitic fluid samples. RESULTS Out of 65 cases, 44 (67.7%) effusions were reported negative, 15 (23.1%) were positive and 6 (9.2%) were suspicious for malignancy. Thus total 21 effusions (32.3%) wer...

BACKGROUND Colposcopy is the gold standard procedure for evaluating cervical cytological abnormalities. Although it is essentially a minimally invasive intervention, referral for colposcopy may cause significant distress on patients. In this study, we aimed to determine if pre-procedural anxiety levels have a significant association with procedure related pain and discomfort in women undergoing...

background & objectives: cancer is a serious problem for human being and is becoming a serious problem day-by-day .a prerequisite for any therapeutic modality is early diagnosis. automated cancer diagnosis by automatic image feature extraction procedures can be used as a feature extraction in the field of fractal dimension. the aim of this survey was to introduce a quantitative and objectiv...

BACKGROUND Epidermal growth factor receptor (EGFR) mutation is predictive for the efficacy of EGFR tyrosine kinase inhibitors in advanced non-small-cell lung cancer (NSCLC) treatment. We evaluated the performance, sensitivity, and concordance between five EGFR tests. MATERIALS AND METHODS DNA admixtures (n = 34; 1%-50% mutant plasmid DNA) and samples from NSCLC patients [116 formalin-fixed pa...

BACKGROUND/AIMS Small core biopsy samples can occasionally be obtained with conventional endoscopic ultrasonography-guided fine needle aspiration (EUS-FNA). Although most studies have focused on the cytological analysis of specimens, data regarding histological assessment is scarce. The aim of this study was to determine whether core biopsies by conventional EUS-FNA could increase the accuracy ...

Nasal cytology is a very useful diagnostic tool in nasal disorders, being able to detect both the cellular modifications of the nasal epithelium caused by either allergen exposure or irritative stimuli (that may be physical or chemical, acute or chronic), or inflammation. Over these past few years, nasal cytology has allowed to identify new disorders, such as the non-allergic rhinitis with eosi...