Methods Our aim in this study was to establish a humanized mouse model to study GMOs by adoptively transferring peripheral blood mononuclear cells from AAI-specific IgE-positive legume allergic and non-allergic individuals into SCID mice. These mice were then gavaged twice weekly for 1 month with GM pea, non-transgenic pea and Tendergreen bean seed meal suspensions or PBS. Subsequently, mice we...

Abstract Background Nasal nitric oxide (nNO), a noninvasive indicator for eosinophilic airway inflammation, has not been adequately studied in different types of rhinitis. The aim this study was to compare nNO levels between allergic (AR) and non-allergic rhinitis (NAR). Patients were included based on their chronic nasal symptoms. Total symptoms score (TNSS) evaluated. measured transnasally wi...

Neopterin is synthesized by human monocyte-derived macrophages upon stimulation with interferon-gamma (IFN-gamma). Measurement of neopterin concentration is useful to monitor cell-mediated (Th1-type) immune activation. In this study, we aimed to analyze the behaviour of neopterin in long lasting asthma considering its role as a marker of the Th1 environment and to establish the distinction betw...

BACKGROUND Nasal provocation with adenosine 5'-monophosphate (AMP) elicits nasal symptoms in subjects with rhinitis. Histamine released from mast cells may play a part in AMP induced nasal responses. METHODS Symptoms of rhinitis were recorded and histamine release in the fluid obtained by nasal lavage after AMP, guanosine 5'-monophosphate (GMP), and placebo instillations was measured in nine ...

OBJECTIVE It is known that mast cells play an important role in pathogenesis of allergic rhinitis. In this study, we investigated the distribution of mast cells in the nasal mucosa of patients with seasonal allergic rhinitis during the pollen-season. METHODS This study was carried out at the Faculty of Medicine, Dicle University, Turkey, during the grass-pollen season between, March and July ...

BACKGROUND There is conflicting evidence that traffic-related air pollution is a risk factor for allergic conditions. Few studies have investigated this in adults. In adults, a high proportion of asthma, rhinitis and eczema is triggered by non-allergic factors. We investigated traffic as a risk factor for allergic versus non-allergic asthma and rhinitis, and eczema, in adults. A questionnaire f...

introduction: chronic suppurative otitis media (csom) is considered one of the most common causes of acquired hearing impairment in developing countries. csom is a multifactorial persistent inflammatory disease of the middle ear. a distinct pathophysiologic mechanism linking allergic rhinitis (ar) and csom remains to evolve. the purpose of this study was to investigate the association between a...