Hodgkin’s lymphoma is a lymphoid tumour that represents about 1% of all de novo neoplasms occurring every year worldwide. Its diagnosis is based on the identification of characteristic neoplastic cells within an inflammatory milieu. Molecular studies have shown that most, if not all cases, belong to the same clonal population, which is derived from peripheral B-cells. The relevance of Epstein-B...

Thiopurines play a pivotal role in the management of inflammatory bowel disease. Azathioprine and mercaptopurine have been associated with a number of liver abnormalities, including hepatitis, veno-occlusive disease, nodular regenerative hyperplasia, and peliosis hepatitis. Patients treated with azathioprine and mercaptopurine have their liver chemistry tests routinely checked due to this poten...

Eighty children aged less than 16 years with newly diagnosed Hodgkin's disease were treated between 1974 and 1982. Complete remission occurred in 95%, with actuarial five year overall survival of 94%, and relapse free survival of 82%: median follow up was 4.8 years. Sixty one children were staged clinically while 19 had staging laparotomies before treatment. Most received combined modality trea...

purpose: to report multiple astrocytic hamartomas in a patient with tuberous sclerosis (ts). patient and findings: a 16-year-old girl with ts without any ocular complaint was referred for ophthalmologic examination. she had papular rash on her face and other skin lesions elsewhere in the body which were specific for ts. multiple well-circumscribed elevated lesions characteristic of astrocytic h...

Background : Diabetic nephropathy is the most common cause of end-stage renal disease and it has various pathologic features. We investigated the clinicopathologic differences between the histologic classes of diabetic nephropathy. Methods : A total of 46 patients with diabetic nephropathy were evaluated. Morphologically, the renal lesions were divided into three categories: class 1, diffuse or...

OBJECTIVE To characterize paramagnetic MRI phase signal abnormalities in neuromyelitis optica spectrum disorder (NMOSD) vs multiple sclerosis (MS) lesions in a cross-sectional study. METHODS Ten patients with NMOSD and 10 patients with relapsing-remitting MS underwent 7-tesla brain MRI including supratentorial T2*-weighted imaging and supratentorial susceptibility weighted imaging. Next, we a...

Abstract Background Tuberous sclerosis is an autosomal dominant neurocutaneous disorder characterized by hamartoma formation in various organ systems leading to highly variable clinical presentation. These patients pose a challenge anesthesiologists due multisystem involvement. Case presentation Herein, we report the successful anesthetic management of 25-year-old parturient with tuberous who u...

Stanford University Medical Center. The use of consensus findings of a panel of pathologists, in 114 of these cases, has confirmed the applicability and reproducibility of this classification. The pathological findings were correlated with the preoperative clinical evaluation in order to assess the anatomic distribution of lesions. Constancy of the histological pattern in multiple lesions was v...

Stanford University Medical Center. The use of consensus findings of a panel of pathologists, in 114 of these cases, has confirmed the applicability and reproducibility of this classification. The pathological findings were correlated with the preoperative clinical evaluation in order to assess the anatomic distribution of lesions. Constancy of the histological pattern in multiple lesions was v...